{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stevens JL"],"funding":["National Institute of Academic Anaesthesia and British Journal of Anaesthesia/Royal College of Anaesthesia Project Grant"],"pagination":["35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10332014"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Background
Tissue injury induces inflammation and the surgical stress response, which are thought to be central to the orchestration of recovery or deterioration after surgery. Enhanced formation of reactive oxygen and nitrogen species accompanies the inflammatory response and triggers separate but integrated reduction/oxidation (redox) pathways that lead to oxidative and/or nitrosative stress (ONS). Quantitative information on ONS in the perioperative period is scarce. This single-centre exploratory study investigated the effects of major surgery on ONS and systemic redox status and their potential associations with postoperative morbidity.Methods
Blood was collected from 56 patients at baseline, end of surgery (EoS) and the first postoperative day (day-1). Postoperative m"],"journal":["Perioperative medicine (London, England)"],"pubmed_title":["Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery."],"pmcid":["PMC10332014"],"funding_grant_id":["537555"],"pubmed_authors":["McKenna HT","Lau L","Filipe H","Murray AJ","Fernandez BO","Stevens JL","Feelisch M","Martin DS"],"additional_accession":[]},"is_claimable":false,"name":"Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery.","description":"Background
Tissue injury induces inflammation and the surgical stress response, which are thought to be central to the orchestration of recovery or deterioration after surgery. Enhanced formation of reactive oxygen and nitrogen species accompanies the inflammatory response and triggers separate but integrated reduction/oxidation (redox) pathways that lead to oxidative and/or nitrosative stress (ONS). Quantitative information on ONS in the perioperative period is scarce. This single-centre exploratory study investigated the effects of major surgery on ONS and systemic redox status and their potential associations with postoperative morbidity.Methods
Blood was collected from 56 patients at baseline, end of surgery (EoS) and the first postoperative day (day-1). Postoperative m","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-20T03:44:55.945Z","creation":"2025-04-20T03:44:55.945Z"},"accession":"S-EPMC10332014","cross_references":{"pubmed":["37430377"],"doi":["10.1186/s13741-023-00325-z"]}}