{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang J"],"funding":["NIAID NIH HHS","Shenzhen Science and Technology Innovation Commission","National Natural Science Foundation of China","Innovation and Technology Commission","Department of Health | National Health and Medical Research Council","National Nanotechnology Initiative"],"pagination":["4079"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10333379"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection and spillover among them. We characterize the mammal-associated viruses in 149 individual bats sampled from Yunnan province, China, using an unbiased meta-transcriptomics approach. This reveals a high frequency of virus co-infection (simultaneous infection of bat individuals by multiple viral species) and spillover among the animals studied, which may in turn facilitate virus recombination and reassortment. Of note, we identify five viral species that are likely to be pathogenic to humans or livestock, based on phylogenetic relatedness to known pathogens or in vitro receptor binding as"],"journal":["Nature communications"],"pubmed_title":["Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential."],"pmcid":["PMC10333379"],"funding_grant_id":["U01 AI151810","32171192","GNT2017197","KQTD20200820145822023","RCJC20210706092009004"],"pubmed_authors":["Gou QY","Shu YL","Li J","Shi M","Feng Y","Gao ZH","Luo HL","Wang J","Kuang GP","Holmes EC","Luo CM","Lv K","Wu WC","Xin GY","Chen YQ","Liang G","Yang LF","Guo D","Li B","Chen S","Pan YF","Yang WH"],"additional_accession":[]},"is_claimable":false,"name":"Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential.","description":"Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection and spillover among them. We characterize the mammal-associated viruses in 149 individual bats sampled from Yunnan province, China, using an unbiased meta-transcriptomics approach. This reveals a high frequency of virus co-infection (simultaneous infection of bat individuals by multiple viral species) and spillover among the animals studied, which may in turn facilitate virus recombination and reassortment. Of note, we identify five viral species that are likely to be pathogenic to humans or livestock, based on phylogenetic relatedness to known pathogens or in vitro receptor binding as","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2026-05-29T14:08:16.523Z","creation":"2025-04-04T20:29:08.73Z"},"accession":"S-EPMC10333379","cross_references":{"pubmed":["37429936"],"doi":["10.1038/s41467-023-39835-1"]}}