biostudies-literaturePan WChinese Research Unit of Tooth Development and Regeneration, Academy of Medical SciencesBeijing Municipal Education CommissionInnovation Research Team Project of Beijing Stomatology Hospital, Capital Medical UniversityBeijing Scholar ProgramNational Natural Science Foundation of ChinaBeijing Municipal Science and Technology CommissionBeijing Advanced Innovation Centre for Big Data-Based Precision MedicineBeijing Municipal Commission of Educatione13395https://www.ebi.ac.uk/biostudies/studies/S-EPMC10334281biostudies-literatureUnknown56(7)Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication that occurs in patients with osteoporosis or metastatic bone cancer treated with bisphosphonate. There is still no effective treatment and prevention strategy for BRONJ. Inorganic nitrate, which is abundant in green vegetables, has been reported to be protective in multiple diseases. To investigate the effects of dietary nitrate on BRONJ-like lesions in mice, we utilized a well-established mouse BRONJ model, in which tooth extraction was performed. Specifically, 4 mM sodium nitrate was administered in advance through drinking water to assess the short- and long-term effects on BRONJ. Zoledronate injection could induce severe healing inhibition of the tooth extraction socket, while addition of pretreating dietCell proliferationDietary nitrate improves jaw bone remodelling in zoledronate-treated mice.PMC10334281PXM2020_014226_000005Z18110000171820891649124CXTD202202PXM2021_014226_00002082122015CXTD2022018230300311192070202012019-12M-5-031PXM2021_014226_000026Pan WWang SXu SGu JZhang CWang JXu JfalseDietary nitrate improves jaw bone remodelling in zoledronate-treated mice.Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication that occurs in patients with osteoporosis or metastatic bone cancer treated with bisphosphonate. There is still no effective treatment and prevention strategy for BRONJ. Inorganic nitrate, which is abundant in green vegetables, has been reported to be protective in multiple diseases. To investigate the effects of dietary nitrate on BRONJ-like lesions in mice, we utilized a well-established mouse BRONJ model, in which tooth extraction was performed. Specifically, 4 mM sodium nitrate was administered in advance through drinking water to assess the short- and long-term effects on BRONJ. Zoledronate injection could induce severe healing inhibition of the tooth extraction socket, while addition of pretreating diet2023-01-01T00:00:00Z2023 Jul2025-04-26T15:10:01.81Z2025-04-06T14:51:02.824ZS-EPMC103342813681090910.1111/cpr.13395