{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nguyen LH"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","NCI","Mark and Lisa Schwartz","NHLBI NIH HHS","Crohn&apos;s and Colitis Foundation","Massachusetts Consortium on Pathogen Readiness","NIDDK","American Gastroenterological Association"],"pagination":["49"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10337137"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>The gut microbiome is a critical modulator of host immunity and is linked to the immune response to respiratory viral infections. However, few studies have gone beyond describing broad compositional alterations in severe COVID-19, defined as acute respiratory or other organ failure.<h4>Methods</h4>We profiled 127 hospitalized patients with COVID-19 (n = 79 with severe COVID-19 and 48 with moderate) who collectively provided 241 stool samples from April 2020 to May 2021 to identify links between COVID-19 severity and gut microbial taxa, their biochemical pathways, and stool metabolites.<h4>Results</h4>Forty-eight species were associated with severe disease after accounting for antibiotic use, age, sex, and various comorbidities. These included significant in-hospital depl"],"journal":["Genome medicine"],"pubmed_title":["Metagenomic assessment of gut microbial communities and risk of severe COVID-19."],"pmcid":["PMC10337137"],"funding_grant_id":["2021-5102","K01 DK120742","K23 DK125838","UL1 TR002541","Research Fellowship Award","K23DK125838","Research Scholars Award","T32 HL116275","K01DK120742","Career Development Award"],"pubmed_authors":["Reinicke T","Woo JE","Magicheva-Gupta M","Drew DA","Kim M","Lai PS","Jesudasen SJ","Thompson KN","Nguyen LH","McIver L","Okin D","Bhosle A","Lo CH","Caraballo A","Chan AT","Huttenhower C","Sui HY","Battista VM","Kuntz TM","Das Adhikari U","Goldberg MB","Kwon DS","Huang CY","Vieira J","Berra L"],"additional_accession":[]},"is_claimable":false,"name":"Metagenomic assessment of gut microbial communities and risk of severe COVID-19.","description":"<h4>Background</h4>The gut microbiome is a critical modulator of host immunity and is linked to the immune response to respiratory viral infections. However, few studies have gone beyond describing broad compositional alterations in severe COVID-19, defined as acute respiratory or other organ failure.<h4>Methods</h4>We profiled 127 hospitalized patients with COVID-19 (n = 79 with severe COVID-19 and 48 with moderate) who collectively provided 241 stool samples from April 2020 to May 2021 to identify links between COVID-19 severity and gut microbial taxa, their biochemical pathways, and stool metabolites.<h4>Results</h4>Forty-eight species were associated with severe disease after accounting for antibiotic use, age, sex, and various comorbidities. These included significant in-hospital depl","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-07-12T03:06:18.158Z","creation":"2025-04-05T00:08:08.216Z"},"accession":"S-EPMC10337137","cross_references":{"pubmed":["37438797"],"doi":["10.1186/s13073-023-01202-6"]}}