biostudies-literatureUnknown13(1)Shavlakadze TRegeneron<h4>Background</h4>As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as "sarcopenia". Sarcopenia is part of the frailty observed in humans. In order to discover treatments for sarcopenia, it is necessary to determine appropriate preclinical models and the genes and signaling pathways that change with age in these models.<h4>Methods and results</h4>To understand the changes in gene expression that occur as a result of aging in skeletal muscles, we generated a multi-time-point gene expression signature throughout the lifespan of mice and rats, as these are the most commonly used species in preclinical research and intervention testing. Gastrocnemius, tibialis anterior, soleus, and diaphragm muscles from maleSkeletal muscle11https://www.ebi.ac.uk/biostudies/studies/S-EPMC10337157biostudies-literatureAge-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes.PMC10337157Negron NXiong KWakai MAtwal GSMishra SGlass DJMcEwen CStec MJSalmon HBai YGadi ANi MWei YShavlakadze TfalseAge-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes.<h4>Background</h4>As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as "sarcopenia". Sarcopenia is part of the frailty observed in humans. In order to discover treatments for sarcopenia, it is necessary to determine appropriate preclinical models and the genes and signaling pathways that change with age in these models.<h4>Methods and results</h4>To understand the changes in gene expression that occur as a result of aging in skeletal muscles, we generated a multi-time-point gene expression signature throughout the lifespan of mice and rats, as these are the most commonly used species in preclinical research and intervention testing. Gastrocnemius, tibialis anterior, soleus, and diaphragm muscles from male2023-01-01T00:00:00Z2023 Jul2026-04-08T12:53:09.856Z2025-04-04T13:51:33.408ZS-EPMC103371573743880710.1186/s13395-023-00321-3