biostudies-literatureFeng MNatural Science Foundation of Shandong Province, ChinaNational Natural Science Foundation of Chinae15660https://www.ebi.ac.uk/biostudies/studies/S-EPMC10340106biostudies-literatureUnknown11Sodium dodecyl sulfate (SDS) is an anionic surfactant, which is widely used in various fields in human life. However, SDS discharged into the water environment has a certain impact on aquatic organisms. In this study, planarian <i>Dugesia japonica</i> (<i>D. japonica</i>) was used to identify the toxic effects of SDS. A series of SDS solutions with different concentrations were used to treat planarians for the acute toxicity test , and the results showed that the semi-lethal concentration (LC₅₀) of SDS to <i>D. japonica</i> at 24 h, 48 h, 72 h, and 96 h were 4.29 mg/L, 3.76 mg/L, 3.45 mg/L, and 3.20 mg/L respectively. After the planarians were exposed to 0.5 mg/L and 1.0 mg/L SDS solutions for 1, 3, and 5 days, the activities of superoxide dismutase (SOD), catalase (CAT), and maPeerJToxic effects of sodium dodecyl sulfate on planarian <i>Dugesia japonica</i>.PMC1034010631350004ZR2011HM06531550005Song LFeng MYin DZhao ZZhou XXu ZfalseToxic effects of sodium dodecyl sulfate on planarian <i>Dugesia japonica</i>.Sodium dodecyl sulfate (SDS) is an anionic surfactant, which is widely used in various fields in human life. However, SDS discharged into the water environment has a certain impact on aquatic organisms. In this study, planarian <i>Dugesia japonica</i> (<i>D. japonica</i>) was used to identify the toxic effects of SDS. A series of SDS solutions with different concentrations were used to treat planarians for the acute toxicity test , and the results showed that the semi-lethal concentration (LC₅₀) of SDS to <i>D. japonica</i> at 24 h, 48 h, 72 h, and 96 h were 4.29 mg/L, 3.76 mg/L, 3.45 mg/L, and 3.20 mg/L respectively. After the planarians were exposed to 0.5 mg/L and 1.0 mg/L SDS solutions for 1, 3, and 5 days, the activities of superoxide dismutase (SOD), catalase (CAT), and ma2023-01-01T00:00:00Z20232025-07-01T03:05:45.817Z2025-07-01T03:05:45.817ZS-EPMC103401063745688410.7717/peerj.15660