{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Xun W"],"pubmed_abstract":["This study was to determine the effects of dietary emodin (ED) on the intestinal mucosal barrier, nuclear factor kappa-B (NF-κB) pathways, and gut microbial flora in lipopolysaccharide (LPS)-induced piglets. Twenty-four weaned piglets were chosen and 4 treatments were created by randomly distributing piglets into CON, ED, LPS, and ED_LPS groups. Experiments were done in a 2 × 2 factorial arrangement and maintained for 21 d. Dietary treatment (a basal diet or 300 mg/kg ED) and immunological challenge (LPS or sterile saline) were 2 major factors. Intraperitoneal injections of LPS or sterilized saline were given to piglets on d 21. Six hours after the LPS challenge, all piglets were euthanized for sample collection and analysis. The results showed that piglets of the ED_LPS group had higher ("],"journal":["Animal nutrition (Zhongguo xu mu shou yi xue hui)"],"pagination":["152-162"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10344667"],"repository":["biostudies-literature"],"pubmed_title":["Dietary emodin alleviates lipopolysaccharide-induced intestinal mucosal barrier injury by regulating gut microbiota in piglets."],"pmcid":["PMC10344667"],"pubmed_authors":["Yang W","Deng T","Shi L","Xun W","Cao T","Ma Z","Ji M","Hou G"],"additional_accession":[]},"is_claimable":false,"name":"Dietary emodin alleviates lipopolysaccharide-induced intestinal mucosal barrier injury by regulating gut microbiota in piglets.","description":"This study was to determine the effects of dietary emodin (ED) on the intestinal mucosal barrier, nuclear factor kappa-B (NF-κB) pathways, and gut microbial flora in lipopolysaccharide (LPS)-induced piglets. Twenty-four weaned piglets were chosen and 4 treatments were created by randomly distributing piglets into CON, ED, LPS, and ED_LPS groups. Experiments were done in a 2 × 2 factorial arrangement and maintained for 21 d. Dietary treatment (a basal diet or 300 mg/kg ED) and immunological challenge (LPS or sterile saline) were 2 major factors. Intraperitoneal injections of LPS or sterilized saline were given to piglets on d 21. Six hours after the LPS challenge, all piglets were euthanized for sample collection and analysis. The results showed that piglets of the ED_LPS group had higher (","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-04-08T19:55:52.305Z","creation":"2025-07-12T03:04:29.186Z"},"accession":"S-EPMC10344667","cross_references":{"pubmed":["37455790"],"doi":["10.1016/j.aninu.2023.05.004"]}}