{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33"],"submitter":["Yang X"],"pubmed_abstract":["We have shown previously that polymorphism of activating transcription factor 6 (ATF6) is associated with susceptibility to hepatocellular carcinoma (HCC). Therefore, genes down-regulated by ATF6 might play a tumor-suppressing role. In the present study, we identified that expression of protein phosphatase magnesium- or manganous-dependent 1H (PPM1H) mRNA and protein can be inhibited by ATF6 in hepatoma cells and mice with liver <i>Atf6</i> knockdown. Tumor tissues from 134 HCC patients were analyzed by immunohistochemistry, and PPM1H exhibited higher expression levels in adjacent para-cancer tissues than in HCC tissues. Therefore, patients with higher expression of PPM1H had a better prognosis. PPM1H inhibited proliferation, migration, and invasion of hepatoma cells. In addition, PPM1H in"],"journal":["Molecular therapy. Nucleic acids"],"pagination":["164-179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10345229"],"repository":["biostudies-literature"],"pubmed_title":["PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit progression of hepatocellular carcinoma."],"pmcid":["PMC10345229"],"pubmed_authors":["Yang X","Li W","Liu Y","Guo J","Li C","Zhu X","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit progression of hepatocellular carcinoma.","description":"We have shown previously that polymorphism of activating transcription factor 6 (ATF6) is associated with susceptibility to hepatocellular carcinoma (HCC). Therefore, genes down-regulated by ATF6 might play a tumor-suppressing role. In the present study, we identified that expression of protein phosphatase magnesium- or manganous-dependent 1H (PPM1H) mRNA and protein can be inhibited by ATF6 in hepatoma cells and mice with liver <i>Atf6</i> knockdown. Tumor tissues from 134 HCC patients were analyzed by immunohistochemistry, and PPM1H exhibited higher expression levels in adjacent para-cancer tissues than in HCC tissues. Therefore, patients with higher expression of PPM1H had a better prognosis. PPM1H inhibited proliferation, migration, and invasion of hepatoma cells. In addition, PPM1H in","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-05-29T10:17:32.697Z","creation":"2025-02-19T04:01:40.052Z"},"accession":"S-EPMC10345229","cross_references":{"pubmed":["37456776"],"doi":["10.1016/j.omtn.2023.06.013"]}}