biostudies-literatureHamilton FWUniversity of Bristol NIHR Biomedical Research CentreMRC Integrative Epidemiology UnitCRUK Integrative Cancer Epidemiology ProgrammeNational Institute for Health Research (NIHR)GW4-CAT Wellcome Trust Doctoral Fellowship SchemeWellcome TrustAcademy of Medical Sciencese000467https://www.ebi.ac.uk/biostudies/studies/S-EPMC10347488biostudies-literatureUnknown2(1)<h4>Objectives</h4>To compare associations between the Gilbert syndrome genotype in European populations, measured bilirubin concentrations, genetically predicted bilirubin using this genotype, and a wide range of health outcomes in a large cohort.<h4>Design</h4>Cohort study including observational, genetic, and Mendelian randomisation analyses.<h4>Setting</h4>22 centres across England, Scotland, and Wales in UK Biobank (2006-10), with replication in a national Finnish cohort (FinnGen).<h4>Participants</h4>463 060 participants in the UK Biobank were successfully genotyped for a genetic variant (rs887829) that is strongly associated with Gilbert syndrome and 438 056 participants had measured bilirubin concentrations with linked electronic health record data coded using the tenth edition of BMJ medicineEffect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associations.PMC10347488SGL029\1006MC_UU_00011/1BRC-1215-2001222894/Z/21/ZCL-2022-25-006202802/Z/16/ZC18281/A29019Timpson NJHamilton FWHamilton WAbeysekera KfalseEffect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associations.<h4>Objectives</h4>To compare associations between the Gilbert syndrome genotype in European populations, measured bilirubin concentrations, genetically predicted bilirubin using this genotype, and a wide range of health outcomes in a large cohort.<h4>Design</h4>Cohort study including observational, genetic, and Mendelian randomisation analyses.<h4>Setting</h4>22 centres across England, Scotland, and Wales in UK Biobank (2006-10), with replication in a national Finnish cohort (FinnGen).<h4>Participants</h4>463 060 participants in the UK Biobank were successfully genotyped for a genetic variant (rs887829) that is strongly associated with Gilbert syndrome and 438 056 participants had measured bilirubin concentrations with linked electronic health record data coded using the tenth edition of 2023-01-01T00:00:00Z20232026-06-16T06:48:42.884Z2024-11-20T16:53:21.132ZS-EPMC103474883745636310.1136/bmjmed-2022-000467