biostudies-literatureUnknown23(1)Geng X<h4>Introduction</h4>Colon cancer remains one of the most prevalent cancers worldwide. Unfortunately, there are no recognized and effective therapeutic strategies to prevent tumor recurrence after radical resection and chemotherapy, and the disease-free survival (DFS) in patients with stage IIIB or IIIC disease remains unsatisfactory. Xian-Lian-Jie-Du optimization decoction (XLJDOD) is a Chinese herbal medicine (CHM) empirical prescription, which has been validated experimentally and clinically that could inhibit the progression of colorectal cancer and ameliorate the symptoms. The purpose of this study is to evaluate the efficacy and safety of XLJDOD in prevention of recurrence of colon cancer.<h4>Methods</h4>This study is a multi-center, double-blind, randomized, placebo-controlled trialBMC complementary medicine and therapies239https://www.ebi.ac.uk/biostudies/studies/S-EPMC10351122biostudies-literatureEfficacy and safety of Xian-Lian-Jie-Du optimization decoction as an adjuvant treatment for prevention of recurrence in patients with stage IIIB/IIIC colon cancer: study protocol for a multicentre, randomized controlled trial.PMC10351122Wu JHuo JChen KGeng XGu YHu WYao QTang DLi LJiang ZFeng LZhao SWang RBu QWang ZZhang BCheng HXu YfalseEfficacy and safety of Xian-Lian-Jie-Du optimization decoction as an adjuvant treatment for prevention of recurrence in patients with stage IIIB/IIIC colon cancer: study protocol for a multicentre, randomized controlled trial.<h4>Introduction</h4>Colon cancer remains one of the most prevalent cancers worldwide. Unfortunately, there are no recognized and effective therapeutic strategies to prevent tumor recurrence after radical resection and chemotherapy, and the disease-free survival (DFS) in patients with stage IIIB or IIIC disease remains unsatisfactory. Xian-Lian-Jie-Du optimization decoction (XLJDOD) is a Chinese herbal medicine (CHM) empirical prescription, which has been validated experimentally and clinically that could inhibit the progression of colorectal cancer and ameliorate the symptoms. The purpose of this study is to evaluate the efficacy and safety of XLJDOD in prevention of recurrence of colon cancer.<h4>Methods</h4>This study is a multi-center, double-blind, randomized, placebo-controlled trial2023-01-01T00:00:00Z2023 Jul2026-05-29T06:00:19.758Z2024-11-05T20:23:21.685ZS-EPMC103511223746103410.1186/s12906-023-04052-2