{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kina UY"],"funding":["NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases","TUBITAK"],"pagination":["e0016723"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10353352"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91(7)"],"pubmed_abstract":["A frequent side effect of chemotherapy against malaria parasite blood infections is a dramatic induction of the sexual blood stages, thereby enhancing the risk of future malaria transmissions. The polyamine biosynthesis pathway has been suggested as a candidate target for transmission-blocking anti-malarial drug development. Herein, we describe the role of a bacterial-type amino acid decarboxylase (<i>AAD</i>) in the life cycle of the malaria model parasite Plasmodium yoelii. Hallmarks of AAD include a conserved catalytic lysine residue and high-level homology to arginine/lysine/ornithine decarboxylases of pathogenic bacteria. By targeted gene deletion, we show that <i>AAD</i> plays an essential role in the exflagellation of microgametes, resulting in complete absence of sporozoites in the"],"journal":["Infection and immunity"],"pubmed_title":["A Candidate Bacterial-Type Amino Acid Decarboxylase Is Essential for Male Gamete Exflagellation and Mosquito Transmission of the Malaria Parasite."],"pmcid":["PMC10353352"],"funding_grant_id":["R21 AI111058","119Z409","1R21AI111058-01A1"],"pubmed_authors":["Deveci G","Kina UY","Rafiqi AM","Matuschewski K","Aly ASI","Kamil M"],"additional_accession":[]},"is_claimable":false,"name":"A Candidate Bacterial-Type Amino Acid Decarboxylase Is Essential for Male Gamete Exflagellation and Mosquito Transmission of the Malaria Parasite.","description":"A frequent side effect of chemotherapy against malaria parasite blood infections is a dramatic induction of the sexual blood stages, thereby enhancing the risk of future malaria transmissions. The polyamine biosynthesis pathway has been suggested as a candidate target for transmission-blocking anti-malarial drug development. Herein, we describe the role of a bacterial-type amino acid decarboxylase (<i>AAD</i>) in the life cycle of the malaria model parasite Plasmodium yoelii. Hallmarks of AAD include a conserved catalytic lysine residue and high-level homology to arginine/lysine/ornithine decarboxylases of pathogenic bacteria. By targeted gene deletion, we show that <i>AAD</i> plays an essential role in the exflagellation of microgametes, resulting in complete absence of sporozoites in the","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-05-29T21:47:21.437Z","creation":"2025-05-29T21:47:21.437Z"},"accession":"S-EPMC10353352","cross_references":{"pubmed":["37260388"],"doi":["10.1128/iai.00167-23"]}}