biostudies-literatureEshun GBBill and Melinda Gates FoundationNational Science Foundation21781-21792https://www.ebi.ac.uk/biostudies/studies/S-EPMC10354592biostudies-literatureUnknown13(31)<i>Fusarium oxysporum</i> (<i>F. oxysporum</i>) is linked to the widespread fusarium wilt in plants affecting the quality and yield of food crops. Management of fusarium wilt by synthetic fertilizers poses safety concerns. Safer-by-design nanomaterials synthesized with a greener approach can meet the needs of commercial antifungal drug resistance. Herein, a simple aqueous reduction method has been adopted for the synthesis of anisotropic gold nanostars (AuNSs) using quercetin-<i>para</i> aminobenzoic acid (QPABA) as both a reducing and stabilizing agent at room temperature for the treatment of <i>F. oxysporum</i>. QPABA was used to control the growth of Au³⁺ star-shaped nanoparticles at increasing concentrations in the ratio of 2 : 1 (QPABA : Au³⁺ ions) respectively. RSC advancesControlled synthesis and computational analysis of gold nanostars for the treatment of <i>Fusarium oxysporum</i>.PMC10354592IOS-1543944Eshun GBOsonga FJSadik OAGolcu AErdogan TfalseControlled synthesis and computational analysis of gold nanostars for the treatment of <i>Fusarium oxysporum</i>.<i>Fusarium oxysporum</i> (<i>F. oxysporum</i>) is linked to the widespread fusarium wilt in plants affecting the quality and yield of food crops. Management of fusarium wilt by synthetic fertilizers poses safety concerns. Safer-by-design nanomaterials synthesized with a greener approach can meet the needs of commercial antifungal drug resistance. Herein, a simple aqueous reduction method has been adopted for the synthesis of anisotropic gold nanostars (AuNSs) using quercetin-<i>para</i> aminobenzoic acid (QPABA) as both a reducing and stabilizing agent at room temperature for the treatment of <i>F. oxysporum</i>. QPABA was used to control the growth of Au³⁺ star-shaped nanoparticles at increasing concentrations in the ratio of 2 : 1 (QPABA : Au³⁺ ions) respectively. 2023-01-01T00:00:00Z2023 Jul2026-03-18T14:08:16.308Z2025-08-23T03:09:02.034ZS-EPMC103545923747603710.1039/d3ra04088g