{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bejjani F"],"funding":["Cancéropôle Grand Ouest","Ligue Contre le Cancer"],"pagination":["129"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10354941"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Background
How transcription factors (TFs) down-regulate gene expression remains ill-understood, especially when they bind to multiple enhancers contacting the same gene promoter. In particular, it is not known whether they exert similar or significantly different molecular effects at these enhancers.Results
To address this issue, we used a particularly well-suited study model consisting of the down-regulation of the TGFB2 gene by the TF Fra-1 in Fra-1-overexpressing cancer cells, as Fra-1 binds to multiple enhancers interacting with the TGFB2 promoter. We show that Fra-1 does not repress TGFB2 transcription via reducing RNA Pol II recruitment at the gene promoter but by decreasing the formation of its transcription-initiating form. This is associated with complex long-rang"],"journal":["Cell & bioscience"],"pubmed_title":["Multiple Fra-1-bound enhancers showing different molecular and functional features can cooperate to repress gene transcription."],"pmcid":["PMC10354941"],"funding_grant_id":["192376","2017-E08","Equipe Labellisée EL2019"],"pubmed_authors":["Piechaczyk M","Bejjani F","Jariel-Encontre I","Zibara K","Tolza C","Evanno E","Mahfoud S"],"additional_accession":[]},"is_claimable":false,"name":"Multiple Fra-1-bound enhancers showing different molecular and functional features can cooperate to repress gene transcription.","description":"Background
How transcription factors (TFs) down-regulate gene expression remains ill-understood, especially when they bind to multiple enhancers contacting the same gene promoter. In particular, it is not known whether they exert similar or significantly different molecular effects at these enhancers.Results
To address this issue, we used a particularly well-suited study model consisting of the down-regulation of the TGFB2 gene by the TF Fra-1 in Fra-1-overexpressing cancer cells, as Fra-1 binds to multiple enhancers interacting with the TGFB2 promoter. We show that Fra-1 does not repress TGFB2 transcription via reducing RNA Pol II recruitment at the gene promoter but by decreasing the formation of its transcription-initiating form. This is associated with complex long-rang","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-07-02T03:04:48.991Z","creation":"2025-07-02T03:04:48.991Z"},"accession":"S-EPMC10354941","cross_references":{"pubmed":["37464380"],"doi":["10.1186/s13578-023-01077-5"]}}