{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Yang S"],"pubmed_abstract":["Chronic exposure to silica can lead to silicosis, one of the most serious occupational lung diseases worldwide, for which there is a lack of effective therapeutic drugs and tools. Epithelial mesenchymal transition plays an important role in several diseases; however, data on the specific mechanisms in silicosis models are scarce. We elucidated the pathogenesis of pulmonary fibrosis via single-cell transcriptome sequencing and constructed an experimental silicosis mouse model to explore the specific molecular mechanisms affecting epithelial mesenchymal transition at the single-cell level. Notably, as silicosis progressed, glycoprotein non-metastatic melanoma protein B (GPNMB) exerted a sustained amplification effect on alveolar type II epithelial cells, inducing epithelial-to-mesenchymal tr"],"journal":["Particle and fibre toxicology"],"pagination":["29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10354944"],"repository":["biostudies-literature"],"pubmed_title":["Single-cell transcriptome sequencing-based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis."],"pmcid":["PMC10354944"],"pubmed_authors":["Yang L","Jiang W","Chao J","Zhang X","Luo W","Long M","Yuan M","Yang S","Sun Y","Zhou X","Cheng Y"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptome sequencing-based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis.","description":"Chronic exposure to silica can lead to silicosis, one of the most serious occupational lung diseases worldwide, for which there is a lack of effective therapeutic drugs and tools. Epithelial mesenchymal transition plays an important role in several diseases; however, data on the specific mechanisms in silicosis models are scarce. We elucidated the pathogenesis of pulmonary fibrosis via single-cell transcriptome sequencing and constructed an experimental silicosis mouse model to explore the specific molecular mechanisms affecting epithelial mesenchymal transition at the single-cell level. Notably, as silicosis progressed, glycoprotein non-metastatic melanoma protein B (GPNMB) exerted a sustained amplification effect on alveolar type II epithelial cells, inducing epithelial-to-mesenchymal tr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-26T11:31:09.734Z","creation":"2024-12-04T01:36:32.136Z"},"accession":"S-EPMC10354944","cross_references":{"pubmed":["37468937"],"doi":["10.1186/s12989-023-00543-9"]}}