{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cha S"],"funding":["National Research Foundation of Korea"],"pagination":["114"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10355033"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Methanotrophs have emerged as promising hosts for the biological conversion of methane into value-added chemicals, including various organic acids. Understanding the mechanisms of acid tolerance is essential for improving organic acid production. WatR, a LysR-type transcriptional regulator, was initially identified as involved in lactate tolerance in a methanotrophic bacterium Methylomonas sp. DH-1. In this study, we investigated the role of WatR as a regulator of cellular defense against weak organic acids and identified novel target genes of WatR.<h4>Results</h4>By conducting an investigation into the genome-wide binding targets of WatR and its role in transcriptional regulation, we identified genes encoding an RND-type efflux pump (WatABO pump) and previously unannota"],"journal":["Biotechnology for biofuels and bioproducts"],"pubmed_title":["Regulation of acetate tolerance by small ORF-encoded polypeptides modulating efflux pump specificity in Methylomonas sp. DH-1."],"pmcid":["PMC10355033"],"funding_grant_id":["2016M3D3A01913245"],"pubmed_authors":["Cho YJ","Lee JK","Hahn JS","Cha S"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of acetate tolerance by small ORF-encoded polypeptides modulating efflux pump specificity in Methylomonas sp. DH-1.","description":"<h4>Background</h4>Methanotrophs have emerged as promising hosts for the biological conversion of methane into value-added chemicals, including various organic acids. Understanding the mechanisms of acid tolerance is essential for improving organic acid production. WatR, a LysR-type transcriptional regulator, was initially identified as involved in lactate tolerance in a methanotrophic bacterium Methylomonas sp. DH-1. In this study, we investigated the role of WatR as a regulator of cellular defense against weak organic acids and identified novel target genes of WatR.<h4>Results</h4>By conducting an investigation into the genome-wide binding targets of WatR and its role in transcriptional regulation, we identified genes encoding an RND-type efflux pump (WatABO pump) and previously unannota","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-05T12:34:14.663Z","creation":"2025-04-05T12:34:14.663Z"},"accession":"S-EPMC10355033","cross_references":{"pubmed":["37464261"],"doi":["10.1186/s13068-023-02364-6"]}}