{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(10)"],"submitter":["Qu J"],"pubmed_abstract":["<b>Background:</b> The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. It is mainly expressed in immune cells such as T cells, B cells and monocytes. In recent years, studies have shown that tumor cell-intrinsic PD-1 plays different roles in the development of melanoma, Liver cancer and lung cancer. However, the expression and function of PD-1 in colon cancer cells has not been reported. Our previous studies have found that <i>Candida tropicalis</i> (<i>C. tropicalis</i>) can promote CRC tumor growth and chemotherapy resistance to oxaliplatin by regulating mismatch repair system. Whether <i>C. tropicalis</i> participates in the progression of CRC and immunotherapy resistance through regula"],"journal":["Journal of Cancer"],"pagination":["1794-1808"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10355211"],"repository":["biostudies-literature"],"pubmed_title":["<i>C. tropicalis</i> promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy."],"pmcid":["PMC10355211"],"pubmed_authors":["Bing Z","Chen Q","Lv M","Wang T","Qu J","Shen S","Hou Y"],"additional_accession":[]},"is_claimable":false,"name":"<i>C. tropicalis</i> promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy.","description":"<b>Background:</b> The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. It is mainly expressed in immune cells such as T cells, B cells and monocytes. In recent years, studies have shown that tumor cell-intrinsic PD-1 plays different roles in the development of melanoma, Liver cancer and lung cancer. However, the expression and function of PD-1 in colon cancer cells has not been reported. Our previous studies have found that <i>Candida tropicalis</i> (<i>C. tropicalis</i>) can promote CRC tumor growth and chemotherapy resistance to oxaliplatin by regulating mismatch repair system. Whether <i>C. tropicalis</i> participates in the progression of CRC and immunotherapy resistance through regula","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-07-14T16:37:15.763Z","creation":"2025-07-04T03:06:05.113Z"},"accession":"S-EPMC10355211","cross_references":{"pubmed":["37476193"],"doi":["10.7150/jca.79664"]}}