biostudies-literatureUnknown14(10)Qu JBackground: The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. It is mainly expressed in immune cells such as T cells, B cells and monocytes. In recent years, studies have shown that tumor cell-intrinsic PD-1 plays different roles in the development of melanoma, Liver cancer and lung cancer. However, the expression and function of PD-1 in colon cancer cells has not been reported. Our previous studies have found that Candida tropicalis (C. tropicalis) can promote CRC tumor growth and chemotherapy resistance to oxaliplatin by regulating mismatch repair system. Whether C. tropicalis participates in the progression of CRC and immunotherapy resistance through regulaJournal of Cancer1794-1808https://www.ebi.ac.uk/biostudies/studies/S-EPMC10355211biostudies-literatureC. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy.PMC10355211Bing ZChen QLv MWang TQu JShen SHou YfalseC. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy.Background: The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. It is mainly expressed in immune cells such as T cells, B cells and monocytes. In recent years, studies have shown that tumor cell-intrinsic PD-1 plays different roles in the development of melanoma, Liver cancer and lung cancer. However, the expression and function of PD-1 in colon cancer cells has not been reported. Our previous studies have found that Candida tropicalis (C. tropicalis) can promote CRC tumor growth and chemotherapy resistance to oxaliplatin by regulating mismatch repair system. Whether C. tropicalis participates in the progression of CRC and immunotherapy resistance through regula2023-01-01T00:00:00Z20232026-07-14T16:37:15.763Z2025-07-04T03:06:05.113ZS-EPMC103552113747619310.7150/jca.79664