{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pan Y"],"funding":["the Postgraduate Tutor Foundation of Harbin Medical University-Daqing","the Scientific Research Fund of Harbin Medical University-Daqing","the Fundamental Research Funds for the Provincial Universities"],"pagination":["87-96"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10355250"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(2)"],"pubmed_abstract":["Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERα coregulators, and has been suggested to be involved in metastasis of several cancers. In ERα-positive breast cancer, PELP1 overexpression enhanced ruffles and filopodium-like structure stimulated by estradiol (E<sub>2</sub>) through extranuclear cell signaling transduction hereby increased cell motility. However, whether PELP1 is also involved in extracellular matrix remodeling of ERα-positive breast cancer cells is still unknown. In this study, we investigated the role of PELP1 in E<sub>2</sub>-induced MMP-9 expression and the underlined mechanism. The results demonstrated the following: E<sub>2</sub>-induced ERα-positive MCF-7 breast c"],"journal":["Hormones & cancer"],"pubmed_title":["Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells."],"pmcid":["PMC10355250"],"funding_grant_id":["JFXN201906","DQ2013-1","DSJJ2015003","JFXN201910"],"pubmed_authors":["Sasano H","Pan Y","Zhang D","Fan Y","Liu L","McNamara K","Zhao B","Liu M","Wang L","Zhang Y","Jia X","Song S","Wang X","Qiao J"],"additional_accession":[]},"is_claimable":false,"name":"Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells.","description":"Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERα coregulators, and has been suggested to be involved in metastasis of several cancers. In ERα-positive breast cancer, PELP1 overexpression enhanced ruffles and filopodium-like structure stimulated by estradiol (E<sub>2</sub>) through extranuclear cell signaling transduction hereby increased cell motility. However, whether PELP1 is also involved in extracellular matrix remodeling of ERα-positive breast cancer cells is still unknown. In this study, we investigated the role of PELP1 in E<sub>2</sub>-induced MMP-9 expression and the underlined mechanism. The results demonstrated the following: E<sub>2</sub>-induced ERα-positive MCF-7 breast c","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-04-18T16:23:15.664Z","creation":"2025-04-07T03:32:51.551Z"},"accession":"S-EPMC10355250","cross_references":{"pubmed":["32037484"],"doi":["10.1007/s12672-020-00380-8"]}}