biostudies-literaturePan Ythe Postgraduate Tutor Foundation of Harbin Medical University-Daqingthe Scientific Research Fund of Harbin Medical University-Daqingthe Fundamental Research Funds for the Provincial Universities87-96https://www.ebi.ac.uk/biostudies/studies/S-EPMC10355250biostudies-literatureUnknown11(2)Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERα coregulators, and has been suggested to be involved in metastasis of several cancers. In ERα-positive breast cancer, PELP1 overexpression enhanced ruffles and filopodium-like structure stimulated by estradiol (E₂) through extranuclear cell signaling transduction hereby increased cell motility. However, whether PELP1 is also involved in extracellular matrix remodeling of ERα-positive breast cancer cells is still unknown. In this study, we investigated the role of PELP1 in E₂-induced MMP-9 expression and the underlined mechanism. The results demonstrated the following: E₂-induced ERα-positive MCF-7 breast cHormones & cancerEstradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells.PMC10355250JFXN201906DQ2013-1DSJJ2015003JFXN201910Sasano HPan YZhang DFan YLiu LMcNamara KZhao BLiu MWang LZhang YJia XSong SWang XQiao JfalseEstradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells.Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERα coregulators, and has been suggested to be involved in metastasis of several cancers. In ERα-positive breast cancer, PELP1 overexpression enhanced ruffles and filopodium-like structure stimulated by estradiol (E₂) through extranuclear cell signaling transduction hereby increased cell motility. However, whether PELP1 is also involved in extracellular matrix remodeling of ERα-positive breast cancer cells is still unknown. In this study, we investigated the role of PELP1 in E₂-induced MMP-9 expression and the underlined mechanism. The results demonstrated the following: E₂-induced ERα-positive MCF-7 breast c2020-01-01T00:00:00Z2020 Apr2025-04-18T16:23:15.664Z2025-04-07T03:32:51.551ZS-EPMC103552503203748410.1007/s12672-020-00380-8