biostudies-literatureWinslow UNovo Nordisk Fondene0288756https://www.ebi.ac.uk/biostudies/studies/S-EPMC10355384biostudies-literatureUnknown18(7)<h4>Objective</h4>Hypokalemia is associated with increased risk of arrhythmias and it is recommended to monitor plasma potassium (p-K) regularly in at-risk patients with cardiovascular diseases. It is poorly understood if administration of potassium supplements and mineralocorticoid receptor antagonists (MRA) aimed at increasing p-K also increases intracellular potassium.<h4>Methods</h4>Adults aged≥18 years with an implantable cardioverter defibrillator (ICD) were randomized (1:1) to a control group or to an intervention that included guidance on potassium rich diets, potassium supplements, and MRA to increase p-K to target levels of 4.5-5.0 mmol/l for six months. Total-body-potassium (TBK) was measured by a Whole-Body-Counter along with p-K at baseline, after six weeks, and after six montPloS oneTreatment-induced increase in total body potassium in patients at high risk of ventricular arrhythmias; a randomized POTCAST substudy.PMC10355384NNF20OC0064048Frandsen EBundgaard HBosselmann HSakthivel TBruun NVinther MLarroude COturai PHaugan KJensen HJRisum NZheng CSaffi HJons CWinslow UIversen KfalseTreatment-induced increase in total body potassium in patients at high risk of ventricular arrhythmias; a randomized POTCAST substudy.<h4>Objective</h4>Hypokalemia is associated with increased risk of arrhythmias and it is recommended to monitor plasma potassium (p-K) regularly in at-risk patients with cardiovascular diseases. It is poorly understood if administration of potassium supplements and mineralocorticoid receptor antagonists (MRA) aimed at increasing p-K also increases intracellular potassium.<h4>Methods</h4>Adults aged≥18 years with an implantable cardioverter defibrillator (ICD) were randomized (1:1) to a control group or to an intervention that included guidance on potassium rich diets, potassium supplements, and MRA to increase p-K to target levels of 4.5-5.0 mmol/l for six months. Total-body-potassium (TBK) was measured by a Whole-Body-Counter along with p-K at baseline, after six weeks, and after six mont2023-01-01T00:00:00Z20232026-05-29T12:20:23.478Z2025-02-19T03:57:02.289ZS-EPMC103553843746722710.1371/journal.pone.0288756