{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Todorova K"],"funding":["Bulgarian National Science Fund"],"pagination":["28-48"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10355945"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Cancer progression is driven by genome instability incurred rearrangements such as transmembrane protease, serine 2 (TMPRSS2)/v-ets erythroblastosis virus E26 oncogene (ERG) that could possibly turn some of the tumor suppressor micro-RNAs into pro-oncogenic ones. Previously, we found dualistic miR-204 effects, acting either as a tumor suppressor or as an oncomiR in ERG fusion-dependent manner. Here, we provided further evidence for an important role of miR-204 for TMPRSS2/ERG and androgen receptor (AR) signaling modulation and fine tuning that prevents TMPRSS2/ERG overexpression in prostate cancer. Based on proximity-based ligation assay, we designed a novel method for detection of TMPRSS2/ERG protein products. We found that miR-204 is TMPRSS2/ERG oncofusion negative regulator, and this wa"],"journal":["Hormones & cancer"],"pubmed_title":["Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer."],"pmcid":["PMC10355945"],"funding_grant_id":["DMU 03/27"],"pubmed_authors":["Fernandez N","Mincheff M","Todorova K","Metodieva G","Metodiev MV","Hayrabedyan S"],"additional_accession":[]},"is_claimable":false,"name":"Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer.","description":"Cancer progression is driven by genome instability incurred rearrangements such as transmembrane protease, serine 2 (TMPRSS2)/v-ets erythroblastosis virus E26 oncogene (ERG) that could possibly turn some of the tumor suppressor micro-RNAs into pro-oncogenic ones. Previously, we found dualistic miR-204 effects, acting either as a tumor suppressor or as an oncomiR in ERG fusion-dependent manner. Here, we provided further evidence for an important role of miR-204 for TMPRSS2/ERG and androgen receptor (AR) signaling modulation and fine tuning that prevents TMPRSS2/ERG overexpression in prostate cancer. Based on proximity-based ligation assay, we designed a novel method for detection of TMPRSS2/ERG protein products. We found that miR-204 is TMPRSS2/ERG oncofusion negative regulator, and this wa","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2026-05-28T09:01:30.528Z","creation":"2025-02-19T04:25:18.919Z"},"accession":"S-EPMC10355945","cross_references":{"pubmed":["28050800"],"doi":["10.1007/s12672-016-0279-9"]}}