{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(13)"],"submitter":["Qiu G"],"pubmed_abstract":["Background This study was performed to identify metabolites associated with incident acute coronary syndrome (ACS) and explore causality of the associations. Methods and Results We performed nontargeted metabolomics in a nested case-control study in the Dongfeng-Tongji cohort, including 500 incident ACS cases and 500 age- and sex-matched controls. Three metabolites, including a novel one (aspartylphenylalanine), and 1,5-anhydro-d-glucitol (1,5-AG) and tetracosanoic acid, were identified as associated with ACS risk, among which aspartylphenylalanine is a degradation product of the gut-brain peptide cholecystokinin-8 rather than angiotensin by the angiotensin-converting enzyme (odds ratio [OR] per SD increase [95% CI], 1.29 [1.13-1.48]; false discovery rate-adjusted <i>P</i>=0.025), 1,5-AG i"],"journal":["Journal of the American Heart Association"],"pagination":["e028540"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10356091"],"repository":["biostudies-literature"],"pubmed_title":["Nontargeted Metabolomics Revealed Novel Association Between Serum Metabolites and Incident Acute Coronary Syndrome: A Mendelian Randomization Study."],"pmcid":["PMC10356091"],"pubmed_authors":["Yang H","Qiu G","Yan Q","Shu XO","He M","Lin Y","Wang H","Xu G","Zhao X","Niu R","Li W","Liu Y","Li X","Li Y","You M","Zhang X","Ouyang Y","Wu T","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"Nontargeted Metabolomics Revealed Novel Association Between Serum Metabolites and Incident Acute Coronary Syndrome: A Mendelian Randomization Study.","description":"Background This study was performed to identify metabolites associated with incident acute coronary syndrome (ACS) and explore causality of the associations. Methods and Results We performed nontargeted metabolomics in a nested case-control study in the Dongfeng-Tongji cohort, including 500 incident ACS cases and 500 age- and sex-matched controls. Three metabolites, including a novel one (aspartylphenylalanine), and 1,5-anhydro-d-glucitol (1,5-AG) and tetracosanoic acid, were identified as associated with ACS risk, among which aspartylphenylalanine is a degradation product of the gut-brain peptide cholecystokinin-8 rather than angiotensin by the angiotensin-converting enzyme (odds ratio [OR] per SD increase [95% CI], 1.29 [1.13-1.48]; false discovery rate-adjusted <i>P</i>=0.025), 1,5-AG i","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2026-05-29T07:22:44.184Z","creation":"2025-02-18T23:24:04.231Z"},"accession":"S-EPMC10356091","cross_references":{"pubmed":["37382146"],"doi":["10.1161/JAHA.122.028540"]}}