{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lim M"],"funding":["NCI NIH HHS"],"pagination":["298-309"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10358007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(5)"],"pubmed_abstract":["We reported previously that bone morphogenetic protein 7 (BMP7) could induce epithelial-mesenchymal transition (EMT) in PC-3 prostate cancer cells grown in tissue culture plates. In this study, we examined BMP7-induced morphological and molecular expression changes that are characteristic of EMT using these cells under both two- (2D) and three-dimensional (3D) culture conditions. Filamentous outgrowths from spheroid structures that were formed from PC-3 cells in 3D cultures were strikingly evident when the spheroids were exposed to extracellular BMP7. This morphological change in 3D was accompanied by down-regulation of E-cadherin, which is an essential adhesion molecule for the integrity of epithelial phenotype. Invasiveness of the cancer cells was significantly enhanced with BMP7 treatme"],"journal":["Hormones & cancer"],"pubmed_title":["PI3K, Erk signaling in BMP7-induced epithelial-mesenchymal transition (EMT) of PC-3 prostate cancer cells in 2- and 3-dimensional cultures."],"pmcid":["PMC10358007"],"funding_grant_id":["R01 CA059705","R01 CA113392","R01 CA59705"],"pubmed_authors":["Chuong CM","Roy-Burman P","Lim M"],"additional_accession":[]},"is_claimable":false,"name":"PI3K, Erk signaling in BMP7-induced epithelial-mesenchymal transition (EMT) of PC-3 prostate cancer cells in 2- and 3-dimensional cultures.","description":"We reported previously that bone morphogenetic protein 7 (BMP7) could induce epithelial-mesenchymal transition (EMT) in PC-3 prostate cancer cells grown in tissue culture plates. In this study, we examined BMP7-induced morphological and molecular expression changes that are characteristic of EMT using these cells under both two- (2D) and three-dimensional (3D) culture conditions. Filamentous outgrowths from spheroid structures that were formed from PC-3 cells in 3D cultures were strikingly evident when the spheroids were exposed to extracellular BMP7. This morphological change in 3D was accompanied by down-regulation of E-cadherin, which is an essential adhesion molecule for the integrity of epithelial phenotype. Invasiveness of the cancer cells was significantly enhanced with BMP7 treatme","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2025-07-04T03:06:01.248Z","creation":"2025-07-04T03:06:01.248Z"},"accession":"S-EPMC10358007","cross_references":{"pubmed":["21948155"],"doi":["10.1007/s12672-011-0084-4"]}}