biostudies-literatureClarke AENCATS NIH HHSNCRR NIH HHSNational Institute for Health Research (NIHR)NIAMS NIH HHSWellcome Trust1859-1870https://www.ebi.ac.uk/biostudies/studies/S-EPMC10363569biostudies-literatureUnknown75(9)<h4>Objective</h4>To estimate direct and indirect costs associated with neuropsychiatric (NP) events in the Systemic Lupus International Collaborating Clinics inception cohort.<h4>Methods</h4>NP events were documented annually using American College of Rheumatology definitions for NP events and attributed to systemic lupus erythematosus (SLE) or non-SLE causes. Patients were stratified into 1 of 3 NP states (no, resolved, or new/ongoing NP event). Change in NP status was characterized by interstate transition rates using multistate modeling. Annual direct costs and indirect costs were based on health care use and impaired productivity over the preceding year. Annual costs associated with NP states and NP events were calculated by averaging all observations in each state and adjusted througArthritis care & researchAssessing the Costs of Neuropsychiatric Disease in the Systemic Lupus International Collaborating Clinics Cohort Using Multistate Modeling.PMC10363569UL1 TR000150UL1 TR001422R01 AR043727P30 AR072579NF-SI-0512-10105NF-SI-0617-10075KL2 TR001424P60 AR064464R01 AR069572K24 AR002138UL1 RR025741M01 RR000046P60 AR048098Urowitz MBWallace DJPetri MDooley MAClarke AESanchez-Guerrero JManzi SJonsen AFortin PRAlarcon GSVan Vollenhoven RFRahman ABernatsky SBruce INFarewell VGinzler EMRamsey-Goldman RRomero-Diaz JGladman DDPeschken CAMerrill JTSt Pierre YBae SCRuiz-Irastorza GKalunian KCAskanase AAranow CHanly JGIsenberg DAGordon CInanc MMackay MLim SSKamen DLJacobsen SfalseAssessing the Costs of Neuropsychiatric Disease in the Systemic Lupus International Collaborating Clinics Cohort Using Multistate Modeling.<h4>Objective</h4>To estimate direct and indirect costs associated with neuropsychiatric (NP) events in the Systemic Lupus International Collaborating Clinics inception cohort.<h4>Methods</h4>NP events were documented annually using American College of Rheumatology definitions for NP events and attributed to systemic lupus erythematosus (SLE) or non-SLE causes. Patients were stratified into 1 of 3 NP states (no, resolved, or new/ongoing NP event). Change in NP status was characterized by interstate transition rates using multistate modeling. Annual direct costs and indirect costs were based on health care use and impaired productivity over the preceding year. Annual costs associated with NP states and NP events were calculated by averaging all observations in each state and adjusted throug2023-01-01T00:00:00Z2023 Sep2026-04-17T13:27:32.474Z2025-04-19T01:43:50.313ZS-EPMC103635693669183810.1002/acr.25090