biostudies-literatureUnknown61(1)Qin XNatural Science Foundation of Anhui ProvinceNational Natural Science Foundation of ChinaClinical Scientific Research Project of the First Affiliated Hospital of Anhui University of Chinese MedicinePostgraduate scientific research project of Anhui University<h4>Context</h4>Qi Teng Xiao Zhuo granule (QTXZG) is a traditional Chinese medicine (TCM) used for therapeutic effects on chronic glomerulonephritis (CGN). However, the underlying mechanism remains unclear.<h4>Objective</h4>To investigate the molecular mechanism of QTXZG on CGN by proteomics.<h4>Materials and methods</h4>The CGN model was induced in Sprague-Dawley rats by injecting adriamycin (3.5 mg/kg, Day 1; 3.0 mg/kg, Day 14) twice through the tail vein. Urine samples were collected on the 21^st day; and the rats divided randomly into control, adriamycin, QTXZG administration groups. Rats in the QTXZG group received QTXZG (10.8 g/kg); control and adriamycin groups were given physiological saline once per day for 30 days. Proteomics was applied to identify the candidate proteiPharmaceutical biology1120-1134https://www.ebi.ac.uk/biostudies/studies/S-EPMC10364565biostudies-literatureIdentification of Rab7 as an autophagy marker: potential therapeutic approaches and the effect of Qi Teng Xiao Zhuo granule in chronic glomerulonephritis.PMC10364565Qin XGao JZhu XChen HXu XfalseIdentification of Rab7 as an autophagy marker: potential therapeutic approaches and the effect of Qi Teng Xiao Zhuo granule in chronic glomerulonephritis.<h4>Context</h4>Qi Teng Xiao Zhuo granule (QTXZG) is a traditional Chinese medicine (TCM) used for therapeutic effects on chronic glomerulonephritis (CGN). However, the underlying mechanism remains unclear.<h4>Objective</h4>To investigate the molecular mechanism of QTXZG on CGN by proteomics.<h4>Materials and methods</h4>The CGN model was induced in Sprague-Dawley rats by injecting adriamycin (3.5 mg/kg, Day 1; 3.0 mg/kg, Day 14) twice through the tail vein. Urine samples were collected on the 21^st day; and the rats divided randomly into control, adriamycin, QTXZG administration groups. Rats in the QTXZG group received QTXZG (10.8 g/kg); control and adriamycin groups were given physiological saline once per day for 30 days. Proteomics was applied to identify the candidate protei2023-01-01T00:00:00Z2023 Dec2025-04-05T07:25:13.218Z2024-11-13T21:42:41.54ZS-EPMC103645653747794910.1080/13880209.2023.2233998