{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Suurmeijer JA"],"funding":["Deltaplan Alvleesklierkanker","NIH","KWF Dutch Cancer Society"],"pagination":["1150-1155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10364758"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109(11)"],"pubmed_abstract":["Background
The recently identified classical and basal-like molecular subtypes of pancreatic cancer impact on overall survival (OS). However, the added value of routine subtyping in both clinical practice and randomized trials is still unclear, as most studies do not consider clinicopathological parameters. This study examined the clinical prognostic value of molecular subtyping in patients with resected pancreatic cancer.Methods
Subtypes were determined on fresh-frozen resected pancreatic cancer samples from three Dutch centres using the Purity Independent Subtyping of Tumours classification. Patient, treatment, and histopathological variables were compared between subtypes. The prognostic value of subtyping in (simulated) pre- and postoperative settings was assessed using"],"journal":["The British journal of surgery"],"pubmed_title":["Impact of classical and basal-like molecular subtypes on overall survival in resected pancreatic cancer in the SPACIOUS-2 multicentre study."],"pmcid":["PMC10364758"],"funding_grant_id":["UVA 2014–6803"],"pubmed_authors":["Suurmeijer JA","Morreau J","Dings MPG","de Guerre L","Soer EC","Strijker M","van de Vijver MJ","Farina Sarasqueta A","Brosens LAA","Dijk F","Slooff RAE","Halfwerk JBG","Bijlsma MF","Busch OR","Besselink MG","van Laarhoven HWM","Verheij J","Kim Y","Groen JV","Offerhaus GJA","Bonsing BA","Dutch Pancreatic Cancer Group","Molenaar IQ"],"additional_accession":[]},"is_claimable":false,"name":"Impact of classical and basal-like molecular subtypes on overall survival in resected pancreatic cancer in the SPACIOUS-2 multicentre study.","description":"Background
The recently identified classical and basal-like molecular subtypes of pancreatic cancer impact on overall survival (OS). However, the added value of routine subtyping in both clinical practice and randomized trials is still unclear, as most studies do not consider clinicopathological parameters. This study examined the clinical prognostic value of molecular subtyping in patients with resected pancreatic cancer.Methods
Subtypes were determined on fresh-frozen resected pancreatic cancer samples from three Dutch centres using the Purity Independent Subtyping of Tumours classification. Patient, treatment, and histopathological variables were compared between subtypes. The prognostic value of subtyping in (simulated) pre- and postoperative settings was assessed using","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-20T01:34:57.913Z","creation":"2024-11-21T05:20:05.486Z"},"accession":"S-EPMC10364758","cross_references":{"pubmed":["35979597"],"doi":["10.1093/bjs/znac272"]}}