{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Parfentyeva V"],"funding":["Generalitat de Catalunya","ISCIII","European Union","LUX4MED special program","“Severo Ochoa” Programme for Centres of Excellence in R&D","FEDER EC","Agencia Estatal de Investigación","Fundació Mir-Puig","Fundació CELLEX Barcelona","SME Instrument SQP","TV3 La Marato"],"pagination":["11982"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10366131"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Time-domain diffuse correlation spectroscopy (TD-DCS) has been introduced as an advancement of the \"classical\" continuous wave DCS (CW-DCS) allowing one to not only to measure depth-resolved blood flow index (BFI) but also to extract optical properties of the measured medium without using any additional diffuse optics technique. However, this method is a photon-starved technique, specially when considering only the late photons that are of primary interest which has limited its in vivo application. In this work, we present a TD-DCS system based on a superconducting nanowire single-photon detector (SNSPD) with a high quantum efficiency, a narrow timing response, and a negligibly low dark count noise. We compared it to the typically used single-photon avalanche diode (SPAD) detector. In addi"],"journal":["Scientific reports"],"pubmed_title":["Fast time-domain diffuse correlation spectroscopy with superconducting nanowire single-photon detector: system validation and in vivo results."],"pmcid":["PMC10366131"],"funding_grant_id":["848827","871124"],"pubmed_authors":["Lanka P","Parfentyeva V","Re R","Pifferi A","Noordzij N","Dalla Mora A","Contini D","Colombo L","Kolarczik M","Durduran T","Torricelli A","Brodu A","Pagliazzi M"],"additional_accession":[]},"is_claimable":false,"name":"Fast time-domain diffuse correlation spectroscopy with superconducting nanowire single-photon detector: system validation and in vivo results.","description":"Time-domain diffuse correlation spectroscopy (TD-DCS) has been introduced as an advancement of the \"classical\" continuous wave DCS (CW-DCS) allowing one to not only to measure depth-resolved blood flow index (BFI) but also to extract optical properties of the measured medium without using any additional diffuse optics technique. However, this method is a photon-starved technique, specially when considering only the late photons that are of primary interest which has limited its in vivo application. In this work, we present a TD-DCS system based on a superconducting nanowire single-photon detector (SNSPD) with a high quantum efficiency, a narrow timing response, and a negligibly low dark count noise. We compared it to the typically used single-photon avalanche diode (SPAD) detector. In addi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-05T14:52:28.212Z","creation":"2025-04-05T14:52:28.212Z"},"accession":"S-EPMC10366131","cross_references":{"pubmed":["37488188"],"doi":["10.1038/s41598-023-39281-5"]}}