{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nguyen S"],"funding":["NIA NIH HHS","National Heart, Lung, and Blood Institute","NHLBI NIH HHS","National Institute on Aging","WHI NIH HHS"],"pagination":["3041-3054"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10366337"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(7)"],"pubmed_abstract":["<h4>Introduction</h4>Physical activity (PA) is prospectively inversely associated with dementia risk, but few studies examined accelerometer measures of PA and sitting with rigorously-adjudicated mild cognitive impairment (MCI) and dementia risk.<h4>Methods</h4>We examined the associations of accelerometer measures (PA and sitting) with incident MCI/probable dementia in the Women's Health Initiative (n = 1277; mean age = 82 ± 6 years) RESULTS: Over a median follow-up of 4.2 years, 267 MCI/probable dementia cases were identified. Adjusted Cox regression HRs (95% CI) across moderate-to-vigorous PA (MVPA) min/d quartiles were 1.00 (reference), 1.28 (0.90 to 1.81), 0.79 (0.53 to 1.17), and 0.69 (0.45 to 1.06); P-trend = 0.01. Adjusted HRs (95% CI) across steps/d quartiles were 1.00 (reference), 0.73 (0.51 to 1.03), 0.64 (0.43 to 0.94), and 0.38 (0.23 to 0.61); P-trend < 0.001. The HR (95% CI) for each 1-SD increment in MVPA (31 min/d) and steps/d (1865) were 0.79 (0.67 to 0.94) and 0.67 (0.54 to 0.82), respectively. Sitting was not associated with MCI/probable dementia.<h4>Discussion</h4>Findings suggest ≥ moderate intensity PA, particularly stepping, associates with lower MCI and dementia risk.<h4>Highlights</h4>Few studies have examined accelerometer-measured physical activity, including steps, and sitting with incident ADRD. Moderate-to-vigorous physical activity and steps, but not light physical activity or sitting, were inversely associated with lower ADRD risk. Among older women, at least moderate intensity physical activity may be needed to reduce ADRD risk."],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Accelerometer-measured physical activity and sitting with incident mild cognitive impairment or probable dementia among older women."],"pmcid":["PMC10366337"],"funding_grant_id":["75N92021D00001","75N92021D00002","5T32AG058529‐04","75N92021D00003","75N92021D00004","75N92021D00005","R01 HL105065","T32 AG058529","P01 AG052352"],"pubmed_authors":["Rapp SR","Manson JE","Nguyen S","Stefanick ML","LaCroix AZ","Di C","Palta P","LaMonte MJ","Bellettiere J","Hayden KM"],"additional_accession":[]},"is_claimable":false,"name":"Accelerometer-measured physical activity and sitting with incident mild cognitive impairment or probable dementia among older women.","description":"<h4>Introduction</h4>Physical activity (PA) is prospectively inversely associated with dementia risk, but few studies examined accelerometer measures of PA and sitting with rigorously-adjudicated mild cognitive impairment (MCI) and dementia risk.<h4>Methods</h4>We examined the associations of accelerometer measures (PA and sitting) with incident MCI/probable dementia in the Women's Health Initiative (n = 1277; mean age = 82 ± 6 years) RESULTS: Over a median follow-up of 4.2 years, 267 MCI/probable dementia cases were identified. Adjusted Cox regression HRs (95% CI) across moderate-to-vigorous PA (MVPA) min/d quartiles were 1.00 (reference), 1.28 (0.90 to 1.81), 0.79 (0.53 to 1.17), and 0.69 (0.45 to 1.06); P-trend = 0.01. Adjusted HRs (95% CI) across steps/d quartiles were 1.00 (reference), 0.73 (0.51 to 1.03), 0.64 (0.43 to 0.94), and 0.38 (0.23 to 0.61); P-trend < 0.001. The HR (95% CI) for each 1-SD increment in MVPA (31 min/d) and steps/d (1865) were 0.79 (0.67 to 0.94) and 0.67 (0.54 to 0.82), respectively. Sitting was not associated with MCI/probable dementia.<h4>Discussion</h4>Findings suggest ≥ moderate intensity PA, particularly stepping, associates with lower MCI and dementia risk.<h4>Highlights</h4>Few studies have examined accelerometer-measured physical activity, including steps, and sitting with incident ADRD. Moderate-to-vigorous physical activity and steps, but not light physical activity or sitting, were inversely associated with lower ADRD risk. Among older women, at least moderate intensity physical activity may be needed to reduce ADRD risk.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2026-06-02T06:39:23.067Z","creation":"2026-05-25T03:07:31.822Z"},"accession":"S-EPMC10366337","cross_references":{"pubmed":["36695426"],"doi":["10.1002/alz.12908"]}}