biostudies-literatureUnknown94Diez-Cirarda M<h4>Background</h4>Cognitive deficits are among the main disabling symptoms in COVID-19 patients and post-COVID syndrome (PCS). Within brain regions, the hippocampus, a key region for cognition, has shown vulnerability to SARS-CoV-2 infection. Therefore, in vivo detailed evaluation of hippocampal changes in PCS patients, validated on post-mortem samples of COVID-19 patients at the acute phase, would shed light into the relationship between COVID-19 and cognition.<h4>Methods</h4>Hippocampal subfields volume, microstructure, and perfusion were evaluated in 84 PCS patients and compared to 33 controls. Associations with blood biomarkers, including glial fibrillary acidic protein (GFAP), myelin oligodendrocyte glycoprotein (MOG), eotaxin-1 (CCL11) and neurofilament light chain (NfL) were evaluaEBioMedicine104711https://www.ebi.ac.uk/biostudies/studies/S-EPMC10366393biostudies-literatureHippocampal subfield abnormalities and biomarkers of pathologic brain changes: from SARS-CoV-2 acute infection to post-COVID syndrome.PMC10366393Cano-Cano FMatias-Guiu Jde la Fuente SMatias-Guiu JAJorquera MPolidura CGonzalez-Rosa JJArrazola JGonzalez-Escamilla GYus-Fuertes MSelma-Calvo BGil-Martinez LGil-Moreno MJGomez-Pinedo UOliver-Mas SBenito-Martin MSOjeda-Hernandez DDiez-Cirarda MSanchez-Sanchez RDelgado-Alonso CValles-Salgado MGomez-Ruiz NfalseHippocampal subfield abnormalities and biomarkers of pathologic brain changes: from SARS-CoV-2 acute infection to post-COVID syndrome.<h4>Background</h4>Cognitive deficits are among the main disabling symptoms in COVID-19 patients and post-COVID syndrome (PCS). Within brain regions, the hippocampus, a key region for cognition, has shown vulnerability to SARS-CoV-2 infection. Therefore, in vivo detailed evaluation of hippocampal changes in PCS patients, validated on post-mortem samples of COVID-19 patients at the acute phase, would shed light into the relationship between COVID-19 and cognition.<h4>Methods</h4>Hippocampal subfields volume, microstructure, and perfusion were evaluated in 84 PCS patients and compared to 33 controls. Associations with blood biomarkers, including glial fibrillary acidic protein (GFAP), myelin oligodendrocyte glycoprotein (MOG), eotaxin-1 (CCL11) and neurofilament light chain (NfL) were evalua2023-01-01T00:00:00Z2023 Aug2025-04-21T16:16:34.138Z2025-04-21T16:16:34.138ZS-EPMC103663933745336410.1016/j.ebiom.2023.104711