{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yarawsky AE"],"funding":["University of Cincinnati","National Institute of General Medical Sciences","NIGMS NIH HHS","NIH HHS"],"pagination":["e4707"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10367597"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(8)"],"pubmed_abstract":["Staphylococcus epidermidis and Staphylococcus aureus are highly problematic bacteria in hospital settings. A major challenge is their ability to form biofilms on abiotic or biotic surfaces. Biofilms are well-organized, multicellular bacterial aggregates that resist antibiotic treatment and often lead to recurrent infections. Bacterial cell wall-anchored (CWA) proteins are important players in biofilm formation and infection. Many have putative stalk-like regions or regions of low complexity near the cell wall-anchoring motif. Recent work demonstrated the strong propensity of the stalk region of S. epidermidis accumulation-associated protein (Aap) to remain highly extended under solution conditions that typically induce compaction. This behavior is consistent with the expected function of a"],"journal":["Protein science : a publication of the Protein Society"],"pubmed_title":["Convergent behavior of extended stalk regions from staphylococcal surface proteins with widely divergent sequence patterns."],"pmcid":["PMC10367597"],"funding_grant_id":["P30 GM138395","R01 GM094363","S10 OD018090","R15 GM115603"],"pubmed_authors":["Ori AL","Herr AB","Whitten ST","English LR","Yarawsky AE"],"additional_accession":[]},"is_claimable":false,"name":"Convergent behavior of extended stalk regions from staphylococcal surface proteins with widely divergent sequence patterns.","description":"Staphylococcus epidermidis and Staphylococcus aureus are highly problematic bacteria in hospital settings. A major challenge is their ability to form biofilms on abiotic or biotic surfaces. Biofilms are well-organized, multicellular bacterial aggregates that resist antibiotic treatment and often lead to recurrent infections. Bacterial cell wall-anchored (CWA) proteins are important players in biofilm formation and infection. Many have putative stalk-like regions or regions of low complexity near the cell wall-anchoring motif. Recent work demonstrated the strong propensity of the stalk region of S. epidermidis accumulation-associated protein (Aap) to remain highly extended under solution conditions that typically induce compaction. This behavior is consistent with the expected function of a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-05T12:35:40.181Z","creation":"2025-04-05T12:35:40.181Z"},"accession":"S-EPMC10367597","cross_references":{"pubmed":["37334491"],"doi":["10.1002/pro.4707","10.1101/2023.01.06.523059"]}}