{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Yu P"],"funding":["NCATS NIH HHS"],"pubmed_abstract":["Inference from immunological data on cells in the adaptive immune system may benefit from modeling specifications that describe variation in the sizes of various clonal sub-populations. We develop one such specification in order to quantify the effects of surrogate selection assays, which we confirm may lead to an enrichment for amplified, potentially disease-relevant T cell clones. Our specification couples within-clonotype birth-death processes with an exchangeable model across clonotypes. Beyond enrichment questions about the surrogate selection design, our framework enables a study of sampling properties of elementary sample diversity statistics; it also points to new statistics that may usefully measure the burden of somatic genomic alterations associated with clonal expansion. We exa"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.07.13.548950"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10369934"],"repository":["biostudies-literature"],"pubmed_title":["SURROGATE SELECTION OVERSAMPLES EXPANDED T CELL CLONOTYPES."],"pmcid":["PMC10369934"],"funding_grant_id":["UL1 TR002373"],"pubmed_authors":["Albertini RJ","Yu P","Lian Y","Albertini MR","Newton MA","Zuleger CL"],"additional_accession":[]},"is_claimable":false,"name":"SURROGATE SELECTION OVERSAMPLES EXPANDED T CELL CLONOTYPES.","description":"Inference from immunological data on cells in the adaptive immune system may benefit from modeling specifications that describe variation in the sizes of various clonal sub-populations. We develop one such specification in order to quantify the effects of surrogate selection assays, which we confirm may lead to an enrichment for amplified, potentially disease-relevant T cell clones. Our specification couples within-clonotype birth-death processes with an exchangeable model across clonotypes. Beyond enrichment questions about the surrogate selection design, our framework enables a study of sampling properties of elementary sample diversity statistics; it also points to new statistics that may usefully measure the burden of somatic genomic alterations associated with clonal expansion. We exa","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-08-23T03:09:10.393Z","creation":"2025-08-23T03:09:10.393Z"},"accession":"S-EPMC10369934","cross_references":{"pubmed":["37503118"],"doi":["10.1101/2023.07.13.548950"]}}