{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Padilla-Benavides T"],"funding":["NIH HHS"],"pagination":["11256"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10378909"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(14)"],"pubmed_abstract":["Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodeling enzymes that are critical for normal cellular functions. mSWI/SNF enzymes are classified into three sub-families based on the presence of specific subunit proteins. The sub-families are Brm- or Brg1-associated factor (BAF), ncBAF (non-canonical BAF), and polybromo-associated BAF (PBAF). The biological roles for the different enzyme sub-families are poorly described. We knocked down the expression of genes encoding unique subunit proteins for each sub-family, <i>Baf250A</i>, <i>Brd9</i>, and <i>Baf180</i>, which mark the BAF, ncBAF, and PBAF sub-families, respectively, and examined the requirement for each in myoblast differentiation. We found that Baf250A and the BAF complex were required to drive lineage-specifi"],"journal":["International journal of molecular sciences"],"pubmed_title":["Differential Contributions of mSWI/SNF Chromatin Remodeler Sub-Families to Myoblast Differentiation."],"pmcid":["PMC10378909"],"funding_grant_id":["R35GM136393","R01AR077578"],"pubmed_authors":["Padilla-Benavides T","Olea-Flores M","Zhang K","Syed SA","Zuniga-Eulogio MD","Sharma T","Navarro-Tito N","Witwicka H","Imbalzano AN"],"additional_accession":[]},"is_claimable":false,"name":"Differential Contributions of mSWI/SNF Chromatin Remodeler Sub-Families to Myoblast Differentiation.","description":"Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodeling enzymes that are critical for normal cellular functions. mSWI/SNF enzymes are classified into three sub-families based on the presence of specific subunit proteins. The sub-families are Brm- or Brg1-associated factor (BAF), ncBAF (non-canonical BAF), and polybromo-associated BAF (PBAF). The biological roles for the different enzyme sub-families are poorly described. We knocked down the expression of genes encoding unique subunit proteins for each sub-family, <i>Baf250A</i>, <i>Brd9</i>, and <i>Baf180</i>, which mark the BAF, ncBAF, and PBAF sub-families, respectively, and examined the requirement for each in myoblast differentiation. We found that Baf250A and the BAF complex were required to drive lineage-specifi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-05T14:50:54.227Z","creation":"2025-04-05T14:50:54.227Z"},"accession":"S-EPMC10378909","cross_references":{"pubmed":["37511016"],"doi":["10.3390/ijms241411256"]}}