{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu W"],"funding":["Modern Agroindustry Technology Research System","National Natural Science Foundation of China"],"pagination":["11573"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10380378"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(14)"],"pubmed_abstract":["DNA methylation is an important epigenetic modification that has been shown to be associated with responses to non-biological stressors. However, there is currently no research on DNA methylation in response to environmental signals in shrimp. In this study, we conducted a comprehensive comparative analysis of DNA methylation profiles and differentially expressed genes between two strains of <i>Litopenaeus vannamei</i> with significantly different cold tolerance through whole genome bisulfite sequencing (WGBS) and transcriptome sequencing. Between Lv-C and Lv-T (constant temperature of 28 °C and low temperatures of 18 °C and 10 °C) under cytosine-guanine (CG) environments, 39,100 differentially methylated regions (DMRs) were identified, corresponding to 9302 DMR-related genes (DMRGs). The "],"journal":["International journal of molecular sciences"],"pubmed_title":["Integrated Analysis of DNA Methylome and Transcriptome Reveals Epigenetic Regulation of Cold Tolerance in <i>Litopenaeus vannamei</i>."],"pmcid":["PMC10380378"],"funding_grant_id":["32072996","32260916","CARS-48"],"pubmed_authors":["Liu Q","Li Q","Zhu W","Wang H","Chen X","Yang C","Peng M","Zhang B","Feng P","Zeng D","Zhao Y","Chen T"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Analysis of DNA Methylome and Transcriptome Reveals Epigenetic Regulation of Cold Tolerance in <i>Litopenaeus vannamei</i>.","description":"DNA methylation is an important epigenetic modification that has been shown to be associated with responses to non-biological stressors. However, there is currently no research on DNA methylation in response to environmental signals in shrimp. In this study, we conducted a comprehensive comparative analysis of DNA methylation profiles and differentially expressed genes between two strains of <i>Litopenaeus vannamei</i> with significantly different cold tolerance through whole genome bisulfite sequencing (WGBS) and transcriptome sequencing. Between Lv-C and Lv-T (constant temperature of 28 °C and low temperatures of 18 °C and 10 °C) under cytosine-guanine (CG) environments, 39,100 differentially methylated regions (DMRs) were identified, corresponding to 9302 DMR-related genes (DMRGs). The ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-20T03:16:00.596Z","creation":"2025-04-20T03:16:00.596Z"},"accession":"S-EPMC10380378","cross_references":{"pubmed":["37511332"],"doi":["10.3390/ijms241411573"]}}