{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Suttorp M"],"funding":["Deutsche Forschungsgemeinschaft","Schornsteinfeger gegen Krebs","Novartis Pharma","Sonnenstrahl e.V."],"pagination":["4776"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10380995"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(14)"],"pubmed_abstract":["Pediatric chronic myeloid leukemia (CML) is a very rare malignancy (age-related incidence 0.1/100,000) typically presenting with leucocyte counts >100,000/µL. However, clinical signs of leukostasis are observed at diagnosis in only approximately 10% of all cases and among these, priapism is infrequent. Here, we analyze data from pediatric CML registries on the occurrence of priapism heralding diagnosis of CML in 16/491 (3.2%) boys (median age 13.5 years, range 4-18) with pediatric CML. In the cohort investigated, duration of priapism resulting in a diagnosis of CML was not reported in 5 patients, and in the remaining 11 patients, occurred as stuttering priapism over 3 months (<i>n</i> = 1), over 6 weeks (<i>n</i> = 1), over 1-2 weeks (<i>n</i> = 2), over several days (<i>n</i> = 2), or 24 "],"journal":["Journal of clinical medicine"],"pubmed_title":["Priapism at Diagnosis of Pediatric Chronic Myeloid Leukemia: Data Derived from a Large Cohort of Children and Teenagers and a Narrative Review on Priapism Management."],"pmcid":["PMC10380995"],"funding_grant_id":["2008/833","SU122/3-1"],"pubmed_authors":["Sembill S","Metzler M","Suttorp M","Kalwak K","Millot F"],"additional_accession":[]},"is_claimable":false,"name":"Priapism at Diagnosis of Pediatric Chronic Myeloid Leukemia: Data Derived from a Large Cohort of Children and Teenagers and a Narrative Review on Priapism Management.","description":"Pediatric chronic myeloid leukemia (CML) is a very rare malignancy (age-related incidence 0.1/100,000) typically presenting with leucocyte counts >100,000/µL. However, clinical signs of leukostasis are observed at diagnosis in only approximately 10% of all cases and among these, priapism is infrequent. Here, we analyze data from pediatric CML registries on the occurrence of priapism heralding diagnosis of CML in 16/491 (3.2%) boys (median age 13.5 years, range 4-18) with pediatric CML. In the cohort investigated, duration of priapism resulting in a diagnosis of CML was not reported in 5 patients, and in the remaining 11 patients, occurred as stuttering priapism over 3 months (<i>n</i> = 1), over 6 weeks (<i>n</i> = 1), over 1-2 weeks (<i>n</i> = 2), over several days (<i>n</i> = 2), or 24 ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2026-04-08T13:08:10.705Z","creation":"2024-11-06T10:47:10.987Z"},"accession":"S-EPMC10380995","cross_references":{"pubmed":["37510891"],"doi":["10.3390/jcm12144776"]}}