biostudies-literatureSuttorp MDeutsche ForschungsgemeinschaftSchornsteinfeger gegen KrebsNovartis PharmaSonnenstrahl e.V.4776https://www.ebi.ac.uk/biostudies/studies/S-EPMC10380995biostudies-literatureUnknown12(14)Pediatric chronic myeloid leukemia (CML) is a very rare malignancy (age-related incidence 0.1/100,000) typically presenting with leucocyte counts >100,000/µL. However, clinical signs of leukostasis are observed at diagnosis in only approximately 10% of all cases and among these, priapism is infrequent. Here, we analyze data from pediatric CML registries on the occurrence of priapism heralding diagnosis of CML in 16/491 (3.2%) boys (median age 13.5 years, range 4-18) with pediatric CML. In the cohort investigated, duration of priapism resulting in a diagnosis of CML was not reported in 5 patients, and in the remaining 11 patients, occurred as stuttering priapism over 3 months (<i>n</i> = 1), over 6 weeks (<i>n</i> = 1), over 1-2 weeks (<i>n</i> = 2), over several days (<i>n</i> = 2), or 24 Journal of clinical medicinePriapism at Diagnosis of Pediatric Chronic Myeloid Leukemia: Data Derived from a Large Cohort of Children and Teenagers and a Narrative Review on Priapism Management.PMC103809952008/833SU122/3-1Sembill SMetzler MSuttorp MKalwak KMillot FfalsePriapism at Diagnosis of Pediatric Chronic Myeloid Leukemia: Data Derived from a Large Cohort of Children and Teenagers and a Narrative Review on Priapism Management.Pediatric chronic myeloid leukemia (CML) is a very rare malignancy (age-related incidence 0.1/100,000) typically presenting with leucocyte counts >100,000/µL. However, clinical signs of leukostasis are observed at diagnosis in only approximately 10% of all cases and among these, priapism is infrequent. Here, we analyze data from pediatric CML registries on the occurrence of priapism heralding diagnosis of CML in 16/491 (3.2%) boys (median age 13.5 years, range 4-18) with pediatric CML. In the cohort investigated, duration of priapism resulting in a diagnosis of CML was not reported in 5 patients, and in the remaining 11 patients, occurred as stuttering priapism over 3 months (<i>n</i> = 1), over 6 weeks (<i>n</i> = 1), over 1-2 weeks (<i>n</i> = 2), over several days (<i>n</i> = 2), or 24 2023-01-01T00:00:00Z2023 Jul2026-04-08T13:08:10.705Z2024-11-06T10:47:10.987ZS-EPMC103809953751089110.3390/jcm12144776