{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arberas-Jimenez I"],"funding":["Centro de Investigación Biomédica en Red","Agencia Canaria de Investigación, Innovación y Sociedad de la Información"],"pagination":["1010"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10384572"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(7)"],"pubmed_abstract":["<i>Naegleria fowleri</i> is the causative agent of a central nervous system affecting disease called primary amoebic meningoencephalitis. It is a fulminant disease with a rapid progression that affects mainly children and young adults who report previous water exposure. Current treatment options are not totally effective and involve several side effects. In this work, six meroterpenoids isolated from the brown algae <i>Gongolaria abies-marina</i> were evaluated against <i>N. fowleri</i>. Gongolarone B (<b>1</b>), 6<i>Z</i>-1'-methoxyamentadione (<b>2</b>), and 1'-methoxyamentadione (<b>3</b>) were the most active molecules against <i>N. fowleri</i> with IC<sub>50</sub> values between 13.27 ± 0.96 µM and 21.92 ± 1.60 µM. However, cystomexicone B (<b>6</b>) was the molecule with the highest "],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Marine Meroterpenoids Isolated from <i>Gongolaria abies-marina</i> Induce Programmed Cell Death in <i>Naegleria fowleri</i>."],"pmcid":["PMC10384572"],"funding_grant_id":["TESIS 2020010117","CB21/13/00100","TESIS 2020010063","TESIS2019010065"],"pubmed_authors":["Pinero JE","Lorenzo-Morales J","Diaz-Marrero AR","Chao-Pellicer J","Rodriguez-Exposito RL","Fernandez JJ","Sifaoui I","San Nicolas-Hernandez D","Arberas-Jimenez I"],"additional_accession":[]},"is_claimable":false,"name":"Marine Meroterpenoids Isolated from <i>Gongolaria abies-marina</i> Induce Programmed Cell Death in <i>Naegleria fowleri</i>.","description":"<i>Naegleria fowleri</i> is the causative agent of a central nervous system affecting disease called primary amoebic meningoencephalitis. It is a fulminant disease with a rapid progression that affects mainly children and young adults who report previous water exposure. Current treatment options are not totally effective and involve several side effects. In this work, six meroterpenoids isolated from the brown algae <i>Gongolaria abies-marina</i> were evaluated against <i>N. fowleri</i>. Gongolarone B (<b>1</b>), 6<i>Z</i>-1'-methoxyamentadione (<b>2</b>), and 1'-methoxyamentadione (<b>3</b>) were the most active molecules against <i>N. fowleri</i> with IC<sub>50</sub> values between 13.27 ± 0.96 µM and 21.92 ± 1.60 µM. However, cystomexicone B (<b>6</b>) was the molecule with the highest ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-20T03:17:32.972Z","creation":"2025-04-20T03:17:32.972Z"},"accession":"S-EPMC10384572","cross_references":{"pubmed":["37513922"],"doi":["10.3390/ph16071010"]}}