{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Y"],"funding":["Zuochong Yu"],"pagination":["243"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10386629"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>Osteosarcoma (OS) is the most prevalent primary malignant bone tumor. However, single-agent chemotherapy exhibits limited efficacy against OS and often encounters tumor resistance. Therefore, we designed and constructed an integrated treatment strategy of photothermal therapy (PTT) combined with chemotherapy and used a surface-encapsulated platelet-osteosarcoma hybrid membrane (OPM) that enhances circulation time and enables OS-specific targeting.<h4>Results</h4>The OPM functions as a shell structure, encapsulating multiple drug-loaded nanocores (BPQDs-DOX) and controlling the release rate of doxorubicin (DOX). Moreover, near-infrared light irradiation accelerates the release of DOX, thereby extending circulation time and enabling photostimulation-responsive release. The"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Black phosphorus quantum dots camouflaged with platelet-osteosarcoma hybrid membrane and doxorubicin for combined therapy of osteosarcoma."],"pmcid":["PMC10386629"],"funding_grant_id":["81602358"],"pubmed_authors":["Xia K","Han B","Zhai Y","Wang Y","Yu Z","Du L","Fei J","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Black phosphorus quantum dots camouflaged with platelet-osteosarcoma hybrid membrane and doxorubicin for combined therapy of osteosarcoma.","description":"<h4>Background</h4>Osteosarcoma (OS) is the most prevalent primary malignant bone tumor. However, single-agent chemotherapy exhibits limited efficacy against OS and often encounters tumor resistance. Therefore, we designed and constructed an integrated treatment strategy of photothermal therapy (PTT) combined with chemotherapy and used a surface-encapsulated platelet-osteosarcoma hybrid membrane (OPM) that enhances circulation time and enables OS-specific targeting.<h4>Results</h4>The OPM functions as a shell structure, encapsulating multiple drug-loaded nanocores (BPQDs-DOX) and controlling the release rate of doxorubicin (DOX). Moreover, near-infrared light irradiation accelerates the release of DOX, thereby extending circulation time and enabling photostimulation-responsive release. The","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-27T00:07:23.184Z","creation":"2025-04-06T17:45:56.292Z"},"accession":"S-EPMC10386629","cross_references":{"pubmed":["37507707"],"doi":["10.1186/s12951-023-02016-9"]}}