biostudies-literatureUnknown9(3)Dillon PF. Hoffmann-La Roche<h4>Background</h4>Multiple sclerosis (MS) is a progressively debilitating neurologic disease that poses significant costs to the healthcare system and workforce.<h4>Objective</h4>To evaluate the impact of MS disease progression on societal costs and quality of life (QoL) using data from the German NeuroTransData (NTD) MS registry.<h4>Methods</h4>Cross-sectional cohort study. The cost cohort included patients with MS disability assessed using Expanded Disability Status Scale (EDSS) in 2019 while the QoL cohort included patients assessed using EDSS and EuroQol-5 Dimension 5-Levels between 2009 and 2019. Direct and indirect medical, and non-medical resource use was quantified and costs derived from public sources.<h4>Results</h4>Within the QoL cohort (<i>n</i> = 9821), QoL worsened with incrMultiple sclerosis journal - experimental, translational and clinical20552173231187810https://www.ebi.ac.uk/biostudies/studies/S-EPMC10387702biostudies-literatureThe socioeconomic impact of disability progression in multiple sclerosis: A retrospective cohort study of the German NeuroTransData (NTD) registry.PMC10387702Braune SMarcelli GWasem JDi Maio DKaramasioti EHeer YDillon PMuros-Le Rouzic EKobelt GfalseThe socioeconomic impact of disability progression in multiple sclerosis: A retrospective cohort study of the German NeuroTransData (NTD) registry.<h4>Background</h4>Multiple sclerosis (MS) is a progressively debilitating neurologic disease that poses significant costs to the healthcare system and workforce.<h4>Objective</h4>To evaluate the impact of MS disease progression on societal costs and quality of life (QoL) using data from the German NeuroTransData (NTD) MS registry.<h4>Methods</h4>Cross-sectional cohort study. The cost cohort included patients with MS disability assessed using Expanded Disability Status Scale (EDSS) in 2019 while the QoL cohort included patients assessed using EDSS and EuroQol-5 Dimension 5-Levels between 2009 and 2019. Direct and indirect medical, and non-medical resource use was quantified and costs derived from public sources.<h4>Results</h4>Within the QoL cohort (<i>n</i> = 9821), QoL worsened with incr2023-01-01T00:00:00Z2023 Jul-Sep2025-04-05T12:35:46.683Z2025-04-05T12:35:46.683ZS-EPMC103877023752962910.1177/20552173231187810