{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Bhasin SS"],"funding":["CURE Childhood Cancer","Woodruff Health Sciences Center"],"pubmed_abstract":["Different driver mutations and/or chromosomal aberrations and dysregulated signaling interactions between leukemia cells and the immune microenvironment have been implicated in the development of T-cell acute lymphoblastic leukemia (T-ALL). To better understand changes in the bone marrow microenvironment and signaling pathways in pediatric T-ALL, bone marrows collected at diagnosis (Dx) and end of induction therapy (EOI) from 11 patients at a single center were profiled by single cell transcriptomics (10 Dx, 5 paired EOI, 1 relapse). T-ALL blasts were identified by comparison with healthy bone marrow cells. T-ALL blast-associated gene signature included SOX4, STMN1, JUN, HES4, CDK6, ARMH1 among the most significantly overexpressed genes, some of which are associated with poor prognosis in "],"journal":["Scientific reports"],"pagination":["12556"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10397284"],"repository":["biostudies-literature"],"pubmed_title":["Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis."],"pmcid":["PMC10397284"],"pubmed_authors":["Sarkar D","Pilcher W","Summers RJ","Emam M","Bhasin SS","Thomas BE","Raikar SS","Bhasin MK","Graham DK","DeRyckere D","Mumme H","Park SI","Castellino SM"],"additional_accession":[]},"is_claimable":false,"name":"Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis.","description":"Different driver mutations and/or chromosomal aberrations and dysregulated signaling interactions between leukemia cells and the immune microenvironment have been implicated in the development of T-cell acute lymphoblastic leukemia (T-ALL). To better understand changes in the bone marrow microenvironment and signaling pathways in pediatric T-ALL, bone marrows collected at diagnosis (Dx) and end of induction therapy (EOI) from 11 patients at a single center were profiled by single cell transcriptomics (10 Dx, 5 paired EOI, 1 relapse). T-ALL blasts were identified by comparison with healthy bone marrow cells. T-ALL blast-associated gene signature included SOX4, STMN1, JUN, HES4, CDK6, ARMH1 among the most significantly overexpressed genes, some of which are associated with poor prognosis in ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-05-28T18:45:18.591Z","creation":"2025-07-06T03:04:11.125Z"},"accession":"S-EPMC10397284","cross_references":{"pubmed":["37532715"],"doi":["10.1038/s41598-023-39152-z"]}}