{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aguilera J"],"funding":["NIEHS NIH HHS","NHLBI NIH HHS"],"pagination":["100093"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10399148"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(2)"],"pubmed_abstract":["<h4>Background</h4>Given the increasing prevalence of wildfires worldwide, understanding the effects of wildfire air pollutants on human health-particularly in specific immunologic pathways-is crucial. Exposure to air pollutants is associated with cardiorespiratory disease; however, immune and epithelial barrier alterations require further investigation.<h4>Objective</h4>We sought to determine the impact of wildfire smoke exposure on the immune system and epithelial barriers by using proteomics and immune cell phenotyping.<h4>Methods</h4>A San Francisco Bay area cohort (n = 15; age 30 ± 10 years) provided blood samples before (October 2019 to March 2020; air quality index = 37) and during (August 2020; air quality index = 80) a major wildfire. Exposure samples were collected 11 days (range"],"journal":["The journal of allergy and clinical immunology. Global"],"pubmed_title":["Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure."],"pmcid":["PMC10399148"],"funding_grant_id":["P01 HL152953","R01 ES032253"],"pubmed_authors":["Heider A","Alkotob S","Nadeau KC","Akdis CA","Cauwenberghs N","Prunicki M","Kaushik A","Aguilera J","Ogulur I","Yazici D","Smith E"],"additional_accession":[]},"is_claimable":false,"name":"Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure.","description":"<h4>Background</h4>Given the increasing prevalence of wildfires worldwide, understanding the effects of wildfire air pollutants on human health-particularly in specific immunologic pathways-is crucial. Exposure to air pollutants is associated with cardiorespiratory disease; however, immune and epithelial barrier alterations require further investigation.<h4>Objective</h4>We sought to determine the impact of wildfire smoke exposure on the immune system and epithelial barriers by using proteomics and immune cell phenotyping.<h4>Methods</h4>A San Francisco Bay area cohort (n = 15; age 30 ± 10 years) provided blood samples before (October 2019 to March 2020; air quality index = 37) and during (August 2020; air quality index = 80) a major wildfire. Exposure samples were collected 11 days (range","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-07-12T03:06:37.681Z","creation":"2025-07-12T03:06:37.681Z"},"accession":"S-EPMC10399148","cross_references":{"pubmed":["37539354"],"doi":["10.1016/j.jacig.2023.100093"]}}