biostudies-literatureUnknown8(30)Murata TThe first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses seven stereogenic centers and that is the core skeleton of almost all of the tanzawaic acid family.ACS omega27703-27709https://www.ebi.ac.uk/biostudies/studies/S-EPMC10399178biostudies-literatureFirst Total Synthesis of Tanzawaic Acid B.PMC10399178Hiraishi SShiina INatsukawa HTsutsui HTateyama STakano AYoshida TSuzuki KMaekawa YUmezaki YShibata NInohana TMurata TKubota HSato TToyoyama KIto KEgashira NYonekura KHonda MTasaki YSuzuki YMori THiraga DfalseFirst Total Synthesis of Tanzawaic Acid B.The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses seven stereogenic centers and that is the core skeleton of almost all of the tanzawaic acid family.2023-01-01T00:00:00Z2023 Aug2025-04-05T00:24:03.636Z2025-04-05T00:24:03.636ZS-EPMC103991783754666710.1021/acsomega.3c03634