{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Darbinian N"],"funding":["NINDS NIH HHS"],"pagination":["160-170"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10399299"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(2)"],"pubmed_abstract":["<h4>Introduction</h4>Cerebral Palsy (CP), the most common cause of disability in children, is phenotypically heterogeneous. Approximately 20% of cases develop severe scoliosis. A pathological hallmark of CP is periventricular leukomalacia (PVL), which is due to dysmyelination, suggesting the possibility of a lipidomic abnormality. Risk factors for CP include perinatal hypoxia, prematurity, multiple gestation, ischemia, infection, and maternal alcohol consumption. There is evidence for low serum levels of omega-3 (ω-3) fatty acids in CP patients, and separately in idiopathic scoliosis. Many effects of free fatty acids (FFAs) are mediated via specific G protein-coupled free fatty acid receptors (FFARs), which play essential roles as nutritional and signaling molecules. FFAs, including ω-3, a"],"journal":["Obstetrics and gynecology research"],"pubmed_title":["Exosomal Lipid Biomarkers of Oligodendrocyte Pathology to Predict Scoliosis in Children with Cerebral Palsy."],"pmcid":["PMC10399299"],"funding_grant_id":["R01 NS097846"],"pubmed_authors":["Samdani A","Goetzl L","Darbinian N","Merabova N","Bachman S","Darbinyan A","Samuel SP","Selzer ME","Calaku K","Sparks EC","Amini S","Tatevosian-Geller T","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Exosomal Lipid Biomarkers of Oligodendrocyte Pathology to Predict Scoliosis in Children with Cerebral Palsy.","description":"<h4>Introduction</h4>Cerebral Palsy (CP), the most common cause of disability in children, is phenotypically heterogeneous. Approximately 20% of cases develop severe scoliosis. A pathological hallmark of CP is periventricular leukomalacia (PVL), which is due to dysmyelination, suggesting the possibility of a lipidomic abnormality. Risk factors for CP include perinatal hypoxia, prematurity, multiple gestation, ischemia, infection, and maternal alcohol consumption. There is evidence for low serum levels of omega-3 (ω-3) fatty acids in CP patients, and separately in idiopathic scoliosis. Many effects of free fatty acids (FFAs) are mediated via specific G protein-coupled free fatty acid receptors (FFARs), which play essential roles as nutritional and signaling molecules. FFAs, including ω-3, a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T09:24:35.819Z","creation":"2025-04-04T09:24:35.819Z"},"accession":"S-EPMC10399299","cross_references":{"pubmed":["37538811"],"doi":["10.26502/ogr0127"]}}