{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Masuda H"],"pubmed_abstract":["We aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer's Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. - 0.14, P = 0.018). The maximu"],"journal":["Scientific reports"],"pagination":["12631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10400628"],"repository":["biostudies-literature"],"pubmed_title":["Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls."],"pmcid":["PMC10400628"],"pubmed_authors":["Tasiro Y","Nakagawa M","Kishi K","Nogami A","Saito Y","Ihara R","Momose T","Shirasawa U","Watanabe A","Saito N","Kagami C","Arima K","Matsuda H","Ootsuki M","Kudo T","Watanabe D","Ogata Y","Kudo Y","Watanabe H","Watanabe M","Tanimoto K","Watanabe K","Uchida T","Kanazawa T","Fukuhara-Kaneumi A","Mimatsu M","Yamazaki M","Ookubo J","Kanazawa J","Kawai T","Tanizaki Y","Uchida E","Fukuyama H","Hisayuki M","Imuta A","Shimohama S","Yamazaki T","Kuwabara Y","Yamasaki S","Sugimori M","Toriihara A","Sato Y","Kuwabara S","Hatashita S","Sasakawa Y","Hashimoto R","Hashimoto M","Fukuhara J","Wada-Isoe K","Saitoh M","Hareyama M","Arashino 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The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer's Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. - 0.14, P = 0.018). The maximu","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-05T12:35:26.618Z","creation":"2025-04-05T12:35:26.618Z"},"accession":"S-EPMC10400628","cross_references":{"pubmed":["37537208"],"doi":["10.1038/s41598-023-38893-1"]}}