biostudies-literatureUnknown13(1)Masuda HWe aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer's Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. - 0.14, P = 0.018). The maximuScientific reports12631https://www.ebi.ac.uk/biostudies/studies/S-EPMC10400628biostudies-literatureHigher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls.PMC10400628Tasiro YNakagawa MKishi KNogami ASaito YIhara RMomose TShirasawa UWatanabe ASaito NKagami CArima KMatsuda HOotsuki MKudo TWatanabe DOgata YKudo YWatanabe HWatanabe MTanimoto KWatanabe KUchida TKanazawa TFukuhara-Kaneumi AMimatsu MYamazaki MOokubo JKanazawa JKawai TTanizaki YUchida EFukuyama HHisayuki MImuta AShimohama SYamazaki TKuwabara YYamasaki SSugimori MToriihara ASato YKuwabara SHatashita SSasakawa YHashimoto RHashimoto MFukuhara JWada-Isoe KSaitoh MHareyama MArashino KToba KSato ASoshi YNishizawa MYamashita ESaitoh YMiyamoto KShibuya HFukumoto SKaneko TDoumoto CMatsuo TNaito KAsada TSato NOota NSato KOkochi MSato HMatsudo HKoyama SYasuda AHayakawa HSakashita HMiki YUtashiro HMiki THayakawa SKonagaya YKishimoto YOdawara TMugikura SShinoto HMatsudo AOchi SKoyama MHayakawa YAnzai YSakurai TKawabe JNakamata NMorihara TKozaki KNakata TEndou HNakata YHanyu HAsano YNakamura YKojima YSakurai HOta TSugawara STaguchi HHiraki HYasaki TSakata TKatou RKatou SSugawara KKatou YMori MMori HMori TYamauchi RWatanabe SNamiki CWatanabe TIwata ATomita NIshizu KNemoto TYamauchi KNagamine SYamauchi HTsukamoto ETakanami CRyokawa AIdegawa MIwata YSakata MMatsui OIda KOgawa KTukamoto THamaguchi CMizukami KHiramatsu SFujishiro HAmanuma MShinohara MMatsui THirano SShimada HAkatsu TTokutake TShinohara TTagami SYamagishi MTakaya MHirano YSaotome KKitayama MWashimi YKanemoto MShiba JIshimori TTerada SSamuraki MTsubota HKondoh YWaragai MAmano NTomioka MIzumida IKimura SWakasaya YKuwano RAkazawa KKimura KMorita SKimura NKatsuyama SUmetsu AWakabayashi RYoshida MIshii KOkamoto KHirano MMiyagi SHayasaka YKinoshita TEbihara YFujisawa HFujita YFujii HFujii KKunimatsu ATakano AKobayashi SKobayashi TTakano DFukuda SKikuchi KOrihara NAriya WTakano HKobayashi KSanjo NSakamoto MSakamoto NHasegawa TNakashima KMasuda HKahashi SSakai KNoda MKomatsu HYano HMuraoka RKowa HKanemaru KTottori KMiyama YShimamura MSakamoto SOuchi YAnami DInagawa SMatsumura JIkegaki JKiuchi KFukaya NShimizu HSamura EMurata TOhtani RSomeya STakahashi TTaoka TMatsumura YTakahashi RTakahashi SOhtani STakahashi MTakahashi JOwa TOhkubo TMinami MOzawa KOgihara TMatsumoto YMajima RIchinose MNagata KFujiwara KAwaji MUnezawa TTakai YKumagai FMizusawa HOno SKawase SSuhara TInoue SKawarabayashi TShinoda KYamada TYamada MMiyata MKudoh MYamada KShimadu TYamada YDoi KOhara TIshihara TTsuji AAkuzawa MSasaki KFurukawa KSasaki MSasaki TKuchii RKikukawa YSatake SNagao RHatakenaka MItoya SYamaoka AKawamata TKashimoto YSatake MSakaibara MAkatuka FNakano NMurayama STagata YHonda AMurayama NAoki RKazui HHonda KChita MHonda HKihara TOkamura NNomura KNishiyama YHong YJTakao MWakebe DMatsushima STuda KKodaka ATsukiyama MNogi ATonbara HNagahusa YOriuti NAtaka SUzawa ASugiyama HSugiyama NOishi YSugiyama MMachida AUeno MUeno KIshiwata AMaeda EFukusumi MKishida ESenda MMaeda KYasui GWada TIkeda YWada RMaeda YSugiura KTakeuchi JMaeda TIkeda STakeuchi RNakada TTakeuchi TShiomi SNishina YMatsubara EYamanaga TTamaru TMatsunari IIchimi NKawaji YIkeda MSuenaga MTakebayashi SAraki NKuranaga MOda HKachi TOuma SMorinaga MSuzuki MKurose SSatomi SHayashi TSuzuki KWashizuka SHayashi NNakahata NKume KHagiwara TOkazaki YMurakami MHagiwara YSinoda TUeda FTokuda THagiwara MUmahara TNii TUeda HKoya EAndo TOkazaki MSekine YOno MHayashi HTakegawa SOno KNishida TObata TObata MSawada SUjita KYoshiyama KTashiro KYoshimaru KHanabusa YNakkamura DShinozaki TMetoki TTokumaru AYoshiyama YTashiro MShimonishi YRyu YKitajima MYamanaka KNakazato YUzuki SUrayama SIHigashida MImai NKubo HSaitou HShingyouji HHirai TShoji MYatabe YKaneda KMiyagawa TYoshimitsu KIchikawa THagiya KOhashi ITakauchi YMiura RSahara TAzuma RYonezawa HTanaka SAdachi MYoshita MTanaka TYonezawa SKanetaka HTanaka MTanaka-Urayama SMiyauchi NTakasugi TTsushima HIkeuchi TSera KNakui AArai YNagasaka TWatanuki STagawa NArai TTsujimoto MYokota OKondo MIseki ETakechi HArai HOkuyama CGoto MIto MImabayashi EGoto SKoide YToyama TIto KIto IIto HIwamoto YHata MFujikawa HYokokoji MKito ANakajima EIwatsubo TNakazawa THirata YYamamoto RKodama TFukushima YTerasaki KYamamoto YSarashina TMuto MYabe MFukushima SDanjo SInuzuka SNiwa KMatsushita MUemura KAkisaki TTahara YMizuno TNiwa FMatsushita TKato MSugishita MYamamoto DYamamoto EYamaguchi KMasao JShiraishi TTakeda NTakeda MIshikawa SToyoshima HShiraishi STakeda SHiguchi MYamaguchi DArahata YIshikawa IMihara BJapanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI)Iwai KKato TKabata KHattori HHoriuchi SOkada YMihara TTakeda AToya NNakagawa TOkada ROkada TNakamuta RfalseHigher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls.We aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer's Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. - 0.14, P = 0.018). The maximu2023-01-01T00:00:00Z2023 Aug2025-04-05T12:35:26.618Z2025-04-05T12:35:26.618ZS-EPMC104006283753720810.1038/s41598-023-38893-1