{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Siebald C"],"funding":["NIDCD NIH HHS","HHS | NIH | National Institute on Deafness and Other Communication Disorders"],"pagination":["e2217033120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10400978"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(31)"],"pubmed_abstract":["Type I spiral ganglion neurons (SGNs) are the auditory afferents that transmit sound information from cochlear inner hair cells (IHCs) to the brainstem. These afferents consist of physiological subtypes that differ in their spontaneous firing rate (SR), activation threshold, and dynamic range and have been described as low, medium, and high SR fibers. Lately, single-cell RNA sequencing experiments have revealed three molecularly defined type I SGN subtypes. The extent to which physiological type I SGN subtypes correspond to molecularly defined subtypes is unclear. To address this question, we have generated mouse lines expressing CreERT2 in SGN subtypes that allow for a physiological assessment of molecular subtypes. We show that <i>Lypd1-CreERT2</i> expressing SGNs represent a well-define"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Molecular signatures define subtypes of auditory afferents with distinct peripheral projection patterns and physiological properties."],"pmcid":["PMC10400978"],"funding_grant_id":["R01 DC019514","R01 DC005965","R01 DC006476","RO1DC019514","T32 DC000023","RO1DC006476","RO1DC005965","T32DC000023"],"pubmed_authors":["Glowatzki E","Sun S","Manca M","Vincent PFY","Muller U","Reijntjes DOJ","Siebald C","Bottom RT"],"additional_accession":[]},"is_claimable":false,"name":"Molecular signatures define subtypes of auditory afferents with distinct peripheral projection patterns and physiological properties.","description":"Type I spiral ganglion neurons (SGNs) are the auditory afferents that transmit sound information from cochlear inner hair cells (IHCs) to the brainstem. These afferents consist of physiological subtypes that differ in their spontaneous firing rate (SR), activation threshold, and dynamic range and have been described as low, medium, and high SR fibers. Lately, single-cell RNA sequencing experiments have revealed three molecularly defined type I SGN subtypes. The extent to which physiological type I SGN subtypes correspond to molecularly defined subtypes is unclear. To address this question, we have generated mouse lines expressing CreERT2 in SGN subtypes that allow for a physiological assessment of molecular subtypes. We show that <i>Lypd1-CreERT2</i> expressing SGNs represent a well-define","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-06-01T20:01:45.01Z","creation":"2025-04-05T09:33:43.299Z"},"accession":"S-EPMC10400978","cross_references":{"pubmed":["37487063"],"doi":["10.1073/pnas.2217033120"]}}