{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["National Natural Science Foundation of China","Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University","Key Research and Development Program of Hubei Province"],"pagination":["e2300516"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10401080"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(22)"],"pubmed_abstract":["The local application of drug-loaded bioactive scaffold materials is one of the important directions to solve the clinical problem of osteoporotic (OP) bone defects. This study retains the advantages of drug loading and mechanical properties of natural 3D bioactive scaffolds. The scaffolds are functionally modified through chemical and self-assembly approaches with application of polydopamine (PDA) nanoparticles and parathyroid hormone-related peptide-1 (PTHrP-1) for efficient local drug loading. This study investigates the effects of the novel bioactive scaffolds on ossification, osteoclastogenesis, and macrophage polarization. This work elucidates the effects of the scaffolds in regulating osteoclastic activity and new bone formation in vitro. Further studies on the establishment and rep"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["A Recombinant Parathyroid Hormone-Related Peptide Locally Applied in Osteoporotic Bone Defect."],"pmcid":["PMC10401080"],"funding_grant_id":["81870162","2022BCA052","81871752","ZNJC202014"],"pubmed_authors":["Lan S","Li J","Hu Y","Chen Z","Zhang Y","Guo X","Cai L","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"A Recombinant Parathyroid Hormone-Related Peptide Locally Applied in Osteoporotic Bone Defect.","description":"The local application of drug-loaded bioactive scaffold materials is one of the important directions to solve the clinical problem of osteoporotic (OP) bone defects. This study retains the advantages of drug loading and mechanical properties of natural 3D bioactive scaffolds. The scaffolds are functionally modified through chemical and self-assembly approaches with application of polydopamine (PDA) nanoparticles and parathyroid hormone-related peptide-1 (PTHrP-1) for efficient local drug loading. This study investigates the effects of the novel bioactive scaffolds on ossification, osteoclastogenesis, and macrophage polarization. This work elucidates the effects of the scaffolds in regulating osteoclastic activity and new bone formation in vitro. Further studies on the establishment and rep","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-18T17:01:14.982Z","creation":"2025-04-07T04:31:18.053Z"},"accession":"S-EPMC10401080","cross_references":{"pubmed":["37229774"],"doi":["10.1002/advs.202300516"]}}