biostudies-literatureUnknown14(7)Yang L<h4>Background</h4>Patients with diabetes mellitus are at higher risk of myocardial ischemia/ reperfusion injury (MI/RI). Shuxin decoction (SXT) is a proven recipe modi-fication from the classic herbal formula "Wu-tou-chi-shi-zhi-wan" according to the traditional Chinese medicine theory. It has been successfully used to alleviate secondary MI/RI in patients with diabetes mellitus in the clinical setting. However, the underlying mechanism is still unclear.<h4>Aim</h4>To further determine the mechanism of SXT in attenuating MI/RI associated with diabetes.<h4>Methods</h4>This paper presents an ensemble model combining network pharmacology and biology. The Traditional Chinese Medicine System Pharmacology Database was accessed to select key components and potential targets of the SXT. In parallWorld journal of diabetes1057-1076https://www.ebi.ac.uk/biostudies/studies/S-EPMC10401449biostudies-literatureNetwork-pharmacology-based research on protective effects and underlying mechanism of Shuxin decoction against myocardial ischemia/reperfusion injury with diabetes.PMC10401449Yang LHuang JZhang ZYLong PHu YHXiao WJHuang SLi YBYang YQi BWMa JWang XJiang CQZhou LFJian YfalseNetwork-pharmacology-based research on protective effects and underlying mechanism of Shuxin decoction against myocardial ischemia/reperfusion injury with diabetes.<h4>Background</h4>Patients with diabetes mellitus are at higher risk of myocardial ischemia/ reperfusion injury (MI/RI). Shuxin decoction (SXT) is a proven recipe modi-fication from the classic herbal formula "Wu-tou-chi-shi-zhi-wan" according to the traditional Chinese medicine theory. It has been successfully used to alleviate secondary MI/RI in patients with diabetes mellitus in the clinical setting. However, the underlying mechanism is still unclear.<h4>Aim</h4>To further determine the mechanism of SXT in attenuating MI/RI associated with diabetes.<h4>Methods</h4>This paper presents an ensemble model combining network pharmacology and biology. The Traditional Chinese Medicine System Pharmacology Database was accessed to select key components and potential targets of the SXT. In parall2023-01-01T00:00:00Z2023 Jul2025-04-27T00:13:40.295Z2025-04-06T17:47:27.601ZS-EPMC104014493754757910.4239/wjd.v14.i7.1057