{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xia C"],"funding":["Science and Technology Commission of Shanghai Municipality","Shanghai Municipal Health Commission","National Natural Science Foundation of China"],"pagination":["1737-1752"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10401544"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(4)"],"pubmed_abstract":["<h4>Background</h4>It has been observed that Slo1 knockout mice have reduced motor function, and people with certain Slo1 mutations have movement problems, but there is no answer whether the movement disorder is caused by the loss of Slo1 in the nervous system, or skeletal muscle, or both. Here, to ascertain in which tissues Slo1 functions to regulate motor function and offer deeper insight in treating related movement disorder, we generated skeletal muscle-specific Slo1 knockout mice, studied the functional changes in Slo1-deficient skeletal muscle and explored the underlying mechanism.<h4>Methods</h4>We used skeletal muscle-specific Slo1 knockout mice (Myf5-Cre; Slo1<sup>flox/flox</sup> mice, called CKO) as in vivo models to examine the role of Slo1 in muscle growth and muscle regenerati"],"journal":["Journal of cachexia, sarcopenia and muscle"],"pubmed_title":["Slo1 deficiency impaired skeletal muscle regeneration and slow-twitch fibre formation."],"pmcid":["PMC10401544"],"funding_grant_id":["18YF1415700","20ZR1435100","82071575","18411964500","2020YJZX0122","16ZR1422000"],"pubmed_authors":["Hu Y","Zhang X","Ma X","Gao Y","Xia C","Chen Y","Jiang T","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Slo1 deficiency impaired skeletal muscle regeneration and slow-twitch fibre formation.","description":"<h4>Background</h4>It has been observed that Slo1 knockout mice have reduced motor function, and people with certain Slo1 mutations have movement problems, but there is no answer whether the movement disorder is caused by the loss of Slo1 in the nervous system, or skeletal muscle, or both. Here, to ascertain in which tissues Slo1 functions to regulate motor function and offer deeper insight in treating related movement disorder, we generated skeletal muscle-specific Slo1 knockout mice, studied the functional changes in Slo1-deficient skeletal muscle and explored the underlying mechanism.<h4>Methods</h4>We used skeletal muscle-specific Slo1 knockout mice (Myf5-Cre; Slo1<sup>flox/flox</sup> mice, called CKO) as in vivo models to examine the role of Slo1 in muscle growth and muscle regenerati","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-07-04T03:06:05.829Z","creation":"2025-07-04T03:06:05.829Z"},"accession":"S-EPMC10401544","cross_references":{"pubmed":["37212018"],"doi":["10.1002/jcsm.13253"]}}