biostudies-literatureWu JChina Scholarship CouncilDeutscher Akademischer AustauschdienstDeutsche ForschungsgemeinschaftSolar Technologies go HybridAlexander von Humboldt-StiftungBayerisches Staatsministerium?f?r Wirtschaft und Medien,?Energie und TechnologieBavarian State GovernmentNational Natural Science Foundation of ChinaTechnical Field Funds of 173 Project16517-16525https://www.ebi.ac.uk/biostudies/studies/S-EPMC10401720biostudies-literatureUnknown145(30)High-throughput synthesis of solution-processable structurally variable small-molecule semiconductors is both an opportunity and a challenge. A large number of diverse molecules provide a possibility for quick material discovery and machine learning based on experimental data. However, the diversity of the molecular structure leads to the complexity of molecular properties, such as solubility, polarity, and crystallinity, which poses great challenges to solution processing and purification. Here, we first report an integrated system for the high-throughput synthesis, purification, and characterization of molecules with a large variety. Based on the principle "Like dissolves like," we combine theoretical calculations and a robotic platform to accelerate the purification of those molecules. Journal of the American Chemical SocietyIntegrated System Built for Small-Molecule Semiconductors via High-Throughput Approaches.PMC1040172044-6521a/20/462104031119960424JJ210663A182849149Wu JBarabash ASeok SIZhang JTorresi LFriederich PBrabec CJXie ZHauch JAZhao YKasian OGuldi DMRocha-Ortiz JSLuo JHu MPerez-Ojeda MEReiser PWang YLahn LfalseIntegrated System Built for Small-Molecule Semiconductors via High-Throughput Approaches.High-throughput synthesis of solution-processable structurally variable small-molecule semiconductors is both an opportunity and a challenge. A large number of diverse molecules provide a possibility for quick material discovery and machine learning based on experimental data. However, the diversity of the molecular structure leads to the complexity of molecular properties, such as solubility, polarity, and crystallinity, which poses great challenges to solution processing and purification. Here, we first report an integrated system for the high-throughput synthesis, purification, and characterization of molecules with a large variety. Based on the principle "Like dissolves like," we combine theoretical calculations and a robotic platform to accelerate the purification of those molecules. 2023-01-01T00:00:00Z2023 Aug2025-04-27T00:04:19.447Z2025-04-06T17:47:44.634ZS-EPMC104017203746734110.1021/jacs.3c03271