biostudies-literatureUnknown24(1)Sidhu V<h4>Background</h4>This study compares the symptomatic 90-day venous thromboembolism (VTE) rates in patients receiving aspirin to patients receiving low-molecular weight heparin (LMWH) or direct oral anticoagulants (DOACs), after total hip (THA) and total knee arthroplasty (TKA).<h4>Methods</h4>Data were collected from a multi-centre cohort study, including demographics, confounders and prophylaxis type (aspirin alone, LMWH alone, aspirin and LMWH, and DOACs). The primary outcome was symptomatic 90-day VTE. Secondary outcomes were major bleeding, joint related reoperation and mortality within 90 days. Data were analysed using logistic regression, the Student's t and Fisher's exact tests (unadjusted) and multivariable regression (adjusted).<h4>Results</h4>There were 1867 eligible patients; BMC musculoskeletal disorders629https://www.ebi.ac.uk/biostudies/studies/S-EPMC10401792biostudies-literatureComparative effectiveness of aspirin for symptomatic venous thromboembolism prophylaxis in patients undergoing total joint arthroplasty, a cohort study.PMC10401792Maree Naylor JSidhu VChurches TBadge HA Harris IAdie SfalseComparative effectiveness of aspirin for symptomatic venous thromboembolism prophylaxis in patients undergoing total joint arthroplasty, a cohort study.<h4>Background</h4>This study compares the symptomatic 90-day venous thromboembolism (VTE) rates in patients receiving aspirin to patients receiving low-molecular weight heparin (LMWH) or direct oral anticoagulants (DOACs), after total hip (THA) and total knee arthroplasty (TKA).<h4>Methods</h4>Data were collected from a multi-centre cohort study, including demographics, confounders and prophylaxis type (aspirin alone, LMWH alone, aspirin and LMWH, and DOACs). The primary outcome was symptomatic 90-day VTE. Secondary outcomes were major bleeding, joint related reoperation and mortality within 90 days. Data were analysed using logistic regression, the Student's t and Fisher's exact tests (unadjusted) and multivariable regression (adjusted).<h4>Results</h4>There were 1867 eligible patients; 2023-01-01T00:00:00Z2023 Aug2025-04-18T22:34:46.467Z2025-04-07T10:19:49.889ZS-EPMC104017923753758010.1186/s12891-023-06750-x